Ordering Recommendation

Use to predict the expression of red blood cell (RBC) antigen specificities, aid in the selection of antigen-negative RBCs for transfusion, assess the risk of alloimmune hemolytic disease, or resolve conflicting serologic antibody results. For fetal testing, order Red Blood Cell Antigen Genotyping, Fetal (3016639) using a fetal specimen. This test does not assess for RhD; to test for RhD, refer to RhD Gene (RHD) Copy Number (0051368).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Lavender (EDTA), Pink (K2EDTA).

Specimen Preparation

Genotyping: Transport 3 mL whole blood. (Min: 1 mL)

Storage/Transport Temperature

Whole blood: Refrigerated

Unacceptable Conditions

Yellow (ACD solution A or B); plasma or serum. Collection of specimens in sodium heparin tubes. Frozen specimens in glass collection tubes.

Remarks
Stability

Whole blood specimen: Ambient: 72 hours; Refrigerated: 1 week; Frozen: 1 month.

Methodology

Polymerase Chain Reaction (PCR)/Fluorescence Monitoring

Performed

Varies

Reported

3-10 days

Reference Interval

Interpretive Data

Refer to report.

Counseling and informed consent are recommended for genetic testing. Consent forms are available online.

Compliance Category

FDA

Note

Hotline History

N/A

CPT Codes

0001U

Components

Component Test Code* Component Chart Name LOINC
3001054 RBC Antigen Genotyping Specimen 31208-2
3001055 Rh Antigen C/c
3001056 Rh Antigen E/e
3001057 Rh Antigen V/VS
3001058 Kell Antigen K/k
3001059 Kell Antigen Kpa/Kpb
3001060 Kell Antigen Jsa/Jsb
3001061 Duffy Antigen Fya/Fyb
3001062 Kidd Antigen Jka/Jkb
3001063 MNS Antigen MN
3001064 MNS Antigen S/s/U
3001065 Lutheran Antigen Lua/Lub
3001066 Dombrock Antigen Doa/Dob
3001067 Dombrock Antigen Hy
3001068 Dombrock Antigen Joa
3001069 Landsteiner-Wiener Antigen LWa/LWb
3001070 Diego Antigen Dia/Dib
3001071 Colton Antigen Coa/Cob
3001072 Scianna Antigen Sc1/Sc2
3001073 Hemoglobin S Antigen
3001074 RBC Antigen Genotyping Interpretation 50398-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Colton genotyping (Coa, Cob)
  • Diego genotyping (Dia, Dib)
  • Dombrock genotyping (Doa, Dob, Hy, Joa)
  • Duffy genotyping (Fya, Fyb, Fyb-67C)
  • Kell genotyping (K, k, Kpa, Kpb, Jsa, Jsb)
  • Kidd genotyping (Jka, Jkb)
  • Landsteiner-Wiener genotyping (LWa, LWb)
  • Lutheran genotyping (Lua, Lub)
  • MNS genotyping (M, N, S, s, U, Uvar, Uneg)
  • Rh genotyping (C, c, E, e, V, VS)
  • Scianna genotyping (Sc1, Sc2)
Red Blood Cell Antigen Genotyping