Ordering Recommendation

Use to provide supporting evidence for a diagnosis of type III hyperlipoproteinemia for evaluation of premature coronary heart disease.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Lavender (EDTA), Pink (K2EDTA), or Yellow (ACD Solution A or B).

Specimen Preparation

Transport 3 mL whole blood. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma or serum. Heparinized specimens. Frozen specimens in glass collection tubes.

Remarks

This test is not recommended for nonsymptomatic patients under 18 years of age.

Stability

Ambient: 72 hours; Refrigerated: 1 week; Frozen: 1 month

Methodology

Polymerase Chain Reaction (PCR)/Fluorescence Monitoring

Performed

Varies

Reported

2-7 days

Reference Interval

Homozygous APOE e3 (e3/e3): This genotype is the most common (normal) genotype.

Interpretive Data

Refer to Report

Counseling and informed consent are recommended for genetic testing. Consent forms are available online.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

N/A

CPT Codes

81401

Components

Component Test Code* Component Chart Name LOINC
2013338 APOE Specimen 31208-2
2013339 APOE Cardiovascular Risk, Genotype 34438-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • APOE
  • ApoE 2 mutations
  • ApoE cardiac risk
  • ApoLipoprotein E Genotype
Apolipoprotein E (APOE) Genotyping, Cardiovascular Risk