Ordering Recommendation

Not recommend except in suspected cases of acquired von Willebrand disease (VWD) or high suspicion of VWD. Preferred initial test is von Willebrand Reflex Profile with reflex to von Willebrand Multimeric Analysis (3020170).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Lt. blue (sodium citrate). refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.

Specimen Preparation

Transfer 3 mL platelet-poor plasma to an ARUP standard transport tube. (Min: 1.5 mL)

Storage/Transport Temperature

CRITCIAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Serum, EDTA plasma, clotted or hemolyzed specimens.

Remarks
Stability

Ambient: 4 hours; Refrigerated: Unacceptable; Frozen: 3 months.

Methodology

Clotting / Microlatex Particle-Mediated Immunoassay / Quantitative Immunoturbidimetry

Performed

Sun-Sat

Reported

1-11 days

Reference Interval

Test Number
Components
Reference Interval
  von Willebrand Factor, Activity (GPIbM)
Age
Reference Intervals (%)
0-6 years 51-215
7-9 years 52-176
10-11 years 60-195
12-13 years 50-184
14-15 years 50-203
16-17 years 49-204
18 years and older 51-215

  Factor VIII, Activity
Age
Reference Interval (%)
0-6 years 56-191
7-9 years 76-199
10-11 years 80-209
12-13 years 72-198
14-15 years 69-237
16-17 years 63-221
18 years and older 56-191

  von Willebrand Factor, Antigen
Age
Reference Interval (%)
0-6 years 52-214
7-9 years 62-180
10-11 years 63-189
12-13 years 60-189
14-15 years 57-199
16-17 years 50-205
18 years and older 52-214

Interpretive Data

  von Willebrand Factor Multimers (0092281) is added automatically to all orders and is performed along with the panel. However, due to the longer turnaround time for multimers testing, the multimers result is reported and charged separately.

Compliance Category

Laboratory Developed Test (LDT)

Note

  von Willebrand Factor Multimers (0092281) is automatically added to all orders and is reported and charged separately.

Hotline History

N/A

CPT Codes

85240; 85246; 85397; VW multimers added separately 85247

Components

Component Test Code* Component Chart Name LOINC
0030095 Factor VIII, Activity 3209-4
0030285 von Willebrand Factor, Antigen 27816-8
3019857 von Willebrand Factor, Activity (GPIbM) 107372-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Factor VIII
  • Vactor VIII, Activity
  • GPIbM
  • von Willebrand Factor (VWF) Activity
  • von Willebrand Factor A
von Willebrand Factor Multimeric Panel