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  von Willebrand Factor Panel With Reflex to von Willebrand Multimers

VW RFLX
Example Reports
Abnormal
Normal

Ordering Recommendation

Recommended reflex panel to diagnose and subclassify suspected von Willebrand disease.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.

Specimen Preparation

Transfer 3 mL platelet-poor plasma to an ARUP standard transport tube. (Min: 1.5 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Serum. Clotted. Nonfrozen or hemolyzed specimens.

Remarks
Stability

Ambient: 4 hours; Refrigerated: Unacceptable; Frozen: 3 months

Methodology

Electrophoresis / Clotting / Microlatex Particle-Mediated Immunoassay / Quantitative Immunoturbidimetry

Performed

Sun-Sat

Reported

1-3 days
If reflexed, add 4-11 days.

Reference Interval

Test Number
 Components
 Reference Interval
  VWF:GPIbM / vWF Antigen Ratio Greater than or equal to 0.7
  von Willebrand Factor, Activity (GPIbM)
Age
 Reference Intervals (%)
0-6 years 51-215
7-9 years 52-176
10-11 years 60-195
12-13 years 50-184
14-15 years 50-203
16-17 years 49-204
18 years and older 51-215

  Factor VIII, Activity
Age
 Reference Interval (%)
0-6 years 56-191
7-9 years 76-199
10-11 years 80-209
12-13 years 72-198
14-15 years 69-237
16-17 years 63-221
18 years and older 56-191

  von Willebrand Factor, Antigen
Age
 Reference Interval (%)
0-6 years 52-214
7-9 years 62-180
10-11 years 63-189
12-13 years 60-189
14-15 years 57-199
16-17 years 50-205
18 years and older 52-214

Interpretive Data



Compliance Category

Modified FDA

Note

  If von Willebrand factor (VWF) GPIbM activity or von Willebrand factor antigen (vWF Ag) or Factor VIII is low, von Willebrand Multimeric Analysis testing will be added.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
01/20/2026
X
N/A

CPT Codes

85240; 85246; 85397; if reflexed, add 85247

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Components

Component Test Code* Component Chart Name LOINC
0030095 Factor VIII, Activity 3209-4
0030285 von Willebrand Factor, Antigen 27816-8
3019857 von Willebrand Factor, Activity (GPIbM) 107372-5
3020248 VWF:GPIbM / vWF Antigen Ratio 107641-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Coag
  • von Willebrand Profile
von Willebrand Factor Panel With Reflex to von Willebrand Multimers