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3017752
Encephalitis Panel With Reflex to Herpes Simplex Virus Types 1 and 2 Glycoprotein G-Specific Antibodies, IgG, CSF
ENCEPH-CSF
Ordering Recommendation
Molecular testing is preferred for patients presenting with meningitis/encephalitis. Refer to Meningitis/Encephalitis Panel by PCR (2013305).
New York DOH Approval Status
This test is not New York state approved. There are no New York state-approved laboratories available and NYDOH is not accepting Non-permitted Laboratory Requests (NPL). Do not submit sample to ARUP.
Specimen Required
Patient Preparation
Collect
CSF.
Specimen Preparation
Transfer 5.0mL CSF to an ARUP standard transport tube. (Min: 2.5mL)
Storage/Transport Temperature
Refrigerated.
Unacceptable Conditions
Serum or plasma. Contaminated, heat-inactivated, or hemolyzed specimens.
Remarks
Stability
Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: 1 month
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA) / Semi-Quantitative Chemiluminescent Immunoassay (CLIA) / Semi-Quantitative Indirect Fluorescent Antibody (IFA)
Performed
Sun-Sat
Reported
4-6 days
Reference Interval
| Test Number |
Components |
Reference Interval |
||||
|---|---|---|---|---|---|---|
| West Nile Virus Antibody IgG CSF | 1.29 IV or less | |||||
| West Nile Virus Antibody IgM CSF | 0.89 IV or less | |||||
| HSV 1/2 Antibody Screen IgG, CSF | 0.89 IV or less | |||||
| Measles, Rubeola, Antibody IgG CSF | 16.4 AU/mL or less | |||||
| Measles, Rubeola, Antibody IgM CSF | Less than 1:2 | |||||
| Mumps Virus Antibody IgG CSF | 10.9 AU/mL or less | |||||
| Mumps Virus Antibody IgM CSF | 0.79 IV or less | |||||
| VZV Antibody IgM CSF | 0.90 ISR or less | |||||
| VZV Antibody IgG CSF |
|
Interpretive Data
| Component |
Interpretation |
|---|---|
| Measles (Rubeola) Antibody, IgG, CSF | 13.4 AU/mL or less: Negative. No significant level of IgG antibody to measles (rubeola) virus detected. 13.5-16.4 AU/mL: Equivocal. Repeat testing in 10-14 days may be helpful. 16.5 AU/mL or greater: Positive. IgG antibody to measles (rubeola) detected, which may indicate a current or past measles (rubeola) infection. |
| Measles (Rubeola) Antibody, IgM, CSF | Less than 1:2: Negative. No evidence of recent infection. False-negative results are possible if the specimen was collected too soon after exposure. 1:2 or greater: Positive. Indicative of recent primary measles infection. |
| Mumps Virus Antibody IgG, CSF | 8.9 AU/mL or less: Negative. No significant level of detectable IgG mumps virus antibody. 9.0-10.9 AU/mL: Equivocal. Repeat testing in 10-14 days may be helpful. 11.0 AU/mL or greater: Positive. IgG antibody to mumps virus detected, which may indicate a current or past mumps virus infection. |
| Mumps Virus Antibody IgM, CSF | 0.79 IV or less: Negative. No significant level of detectable IgM antibody to mumps virus. 0.80-1.20 IV: Equivocal. Borderline levels of IgM antibody to mumps virus. Repeat testing in 10-14 days may be helpful. 1.21 IV or greater: Positive. Presence of IgM antibody to mumps virus detected, which may indicate a current or recent infection. However, low levels of IgM antibody may occasionally persist for more than 12 months post infection or immunization. |
| Varicella-Zoster Virus Antibody, IgG, CSF | Less than or equal to 0.99 S/CO: Negative: No significant level of IgG antibody to varicella-zoster virus detected. Greater than or equal to 1.00 S/CO: Positive: IgG antibody to varicella-zoster virus detected, which may indicate a current or past varicella-zoster infection. |
| Varicella-Zoster Virus Antibody, IgM by ELISA (CSF) | 0.90 ISR or less: Negative. No significant level of IgM antibody to varicella-zoster virus detected. 0.91-1.09 ISR: Equivocal. Repeat testing in 10-14 days may be helpful. 1.10 ISR or greater: Positive. Significant level of IgM antibody to varicella-zoster virus detected, which may indicate current or recent infection. However, low levels of IgM antibodies may occasionally persist for more than 12 months post infection. |
| Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG, CSF | 0.89 IV or less: Negative. No significant level of detectable HSV IgG antibody. 0.90-1.09 IV: Equivocal. Questionable presence of IgG antibodies. Repeat testing in 10-14 days may be helpful. 1.10 IV or greater: Positive. IgG antibody to HSV detected which may indicate a current or past HSV infection. |
| West Nile Virus Antibody, IgG by ELISA, CSF | 1.29 IV or less: Negative. No significant level of West Nile virus IgG antibody detected. 1.30-1.49 IV: Equivocal. Questionable presence of West Nile virus IgG antibody detected. Repeat testing in 10-14 days may be helpful. 1.50 IV or greater: Positive. Presence of IgG antibody to West Nile virus detected, suggestive of current or past infection. |
| West Nile Virus Antibody, IgM by ELISA, CSF | 0.89 IV or less: Negative. No significant level of West Nile virus IgM antibody detected. 0.90-1.10 IV: Equivocal. Questionable presence of West Nile virus IgM antibody detected. Repeat testing in 10-14 days may be helpful. 1.11 IV or greater: Positive. Presence of IgM antibody to West Nile virus detected, suggestive of current or recent infection. |
Compliance Category
Laboratory Developed Test (LDT)
Note
If HSV 1 and/or 2 IgG, CSF is 1.10 IV or greater, then HSV 1 G-specific IgG, CSF and HSV 2 G-specific IgG, CSF will be added. Additional charges apply.
Hotline History
Hotline History
Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
N/A
CPT Codes
86765 x2; 86735 x2; 86787 x2; 86789; 86788; 86694; if reflexed, add 86695; 86696
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0050238 | West Nile Virus Antibody IgG CSF | 39572-3 |
| 0050239 | West Nile Virus Antibody IgM CSF | 39573-1 |
| 0050394 | HSV 1/2 Antibody Screen IgG, CSF | 13249-8 |
| 0054440 | Measles, Rubeola, Antibody IgG CSF | 9566-1 |
| 0054441 | Measles, Rubeola, Antibody IgM CSF | 21502-0 |
| 0054442 | Mumps Virus Antibody IgG CSF | 13266-2 |
| 0054443 | Mumps Virus Antibody IgM CSF | 13267-0 |
| 0054444 | VZV Antibody IgG CSF | 58755-0 |
| 0054445 | VZV Antibody IgM CSF | 31695-0 |
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
Encephalitis Panel With Reflex to Herpes Simplex Virus Types 1 and 2 Glycoprotein G-Specific Antibodies, IgG, CSF
