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3017752
Encephalitis Panel With Reflex to Herpes Simplex Virus Types 1 and 2 Glycoprotein G-Specific Antibodies, IgG, CSF
ENCEPH-CSF
Ordering Recommendation
Molecular testing is preferred for patients presenting with meningitis/encephalitis. Refer to Meningitis/Encephalitis Panel by PCR (2013305).
New York DOH Approval Status
This test is not New York state approved. There are no New York state-approved laboratories available and NYSDOH is not accepting Single Use Permit (SUP) requests. Do not submit sample to ARUP.
Specimen Required
Patient Preparation
Collect
CSF.
Specimen Preparation
Transfer 5.0mL CSF to an ARUP standard transport tube. (Min: 2.5mL)
Storage/Transport Temperature
Refrigerated.
Unacceptable Conditions
Serum or plasma. Contaminated, heat-inactivated, or hemolyzed specimens.
Remarks
Stability
Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: 1 month
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA) / Semi-Quantitative Chemiluminescent Immunoassay (CLIA) / Semi-Quantitative Indirect Fluorescent Antibody (IFA)
Performed
Sun-Sat
Reported
4-6 days
Reference Interval
| Test Number |
Components |
Reference Interval |
|---|---|---|
| West Nile Virus Antibody IgG CSF | 1.29 IV or less | |
| West Nile Virus Antibody IgM CSF | 0.89 IV or less | |
| HSV 1/2 Antibody Screen IgG, CSF | 0.89 IV or less | |
| Measles, Rubeola, Antibody IgG CSF | Less than or equal to 13.4 AU/mL | |
| Measles, Rubeola, Antibody IgM CSF | Less than 1:2 | |
| Mumps Virus Antibody IgG CSF | Less than or equal to 8.9 AU/mL | |
| Mumps Virus Antibody IgM CSF | 0.79 IV or less | |
| VZV Antibody IgM CSF | 0.90 ISR or less | |
| VZV Antibody IgG CSF | 0.99 S/CO or less |
Interpretive Data
| Component |
Interpretation |
|---|---|
| Measles (Rubeola) Antibody, IgG, CSF | 13.4 AU/mL or less: Negative. No significant level of IgG antibody to measles (rubeola) virus detected. 13.5-16.4 AU/mL: Equivocal. Repeat testing in 10-14 days may be helpful. 16.5 AU/mL or greater: Positive. IgG antibody to measles (rubeola) detected, which may indicate a current or past measles (rubeola) infection. |
| Measles (Rubeola) Antibody, IgM, CSF | Less than 1:2: Negative. No evidence of recent infection. False-negative results are possible if the specimen was collected too soon after exposure. 1:2 or greater: Positive. Indicative of recent primary measles infection. |
| Mumps Virus Antibody IgG, CSF | 8.9 AU/mL or less: Negative. No significant level of detectable IgG mumps virus antibody. 9.0-10.9 AU/mL: Equivocal. Repeat testing in 10-14 days may be helpful. 11.0 AU/mL or greater: Positive. IgG antibody to mumps virus detected, which may indicate a current or past mumps virus infection. |
| Mumps Virus Antibody IgM, CSF | 0.79 IV or less: Negative. No significant level of detectable IgM antibody to mumps virus. 0.80-1.20 IV: Equivocal. Borderline levels of IgM antibody to mumps virus. Repeat testing in 10-14 days may be helpful. 1.21 IV or greater: Positive. Presence of IgM antibody to mumps virus detected, which may indicate a current or recent infection. However, low levels of IgM antibody may occasionally persist for more than 12 months post infection or immunization. |
| Varicella-Zoster Virus Antibody, IgG, CSF | Less than or equal to 0.99 S/CO: Negative: No significant level of IgG antibody to varicella-zoster virus detected. Greater than or equal to 1.00 S/CO: Positive: IgG antibody to varicella-zoster virus detected, which may indicate a current or past varicella-zoster infection. |
| Varicella-Zoster Virus Antibody, IgM by ELISA (CSF) | 0.90 ISR or less: Negative. No significant level of IgM antibody to varicella-zoster virus detected. 0.91-1.09 ISR: Equivocal. Repeat testing in 10-14 days may be helpful. 1.10 ISR or greater: Positive. Significant level of IgM antibody to varicella-zoster virus detected, which may indicate current or recent infection. However, low levels of IgM antibodies may occasionally persist for more than 12 months post infection. |
| Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG, CSF | 0.89 IV or less: Negative. No significant level of detectable HSV IgG antibody. 0.90-1.09 IV: Equivocal. Questionable presence of IgG antibodies. Repeat testing in 10-14 days may be helpful. 1.10 IV or greater: Positive. IgG antibody to HSV detected which may indicate a current or past HSV infection. |
| West Nile Virus Antibody, IgG by ELISA, CSF | 1.29 IV or less: Negative. No significant level of West Nile virus IgG antibody detected. 1.30-1.49 IV: Equivocal. Questionable presence of West Nile virus IgG antibody detected. Repeat testing in 10-14 days may be helpful. 1.50 IV or greater: Positive. Presence of IgG antibody to West Nile virus detected, suggestive of current or past infection. |
| West Nile Virus Antibody, IgM by ELISA, CSF | 0.89 IV or less: Negative. No significant level of West Nile virus IgM antibody detected. 0.90-1.10 IV: Equivocal. Questionable presence of West Nile virus IgM antibody detected. Repeat testing in 10-14 days may be helpful. 1.11 IV or greater: Positive. Presence of IgM antibody to West Nile virus detected, suggestive of current or recent infection. |
Compliance Category
Laboratory Developed Test (LDT)
Note
If HSV 1 and/or 2 IgG, CSF is 1.10 IV or greater, then HSV 1 G-specific IgG, CSF and HSV 2 G-specific IgG, CSF will be added. Additional charges apply.
Hotline History
Hotline History
Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
N/A
CPT Codes
86765 x2; 86735 x2; 86787 x2; 86789; 86788; 86694; if reflexed, add 86695; 86696
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0050238 | West Nile Virus Antibody IgG CSF | 39572-3 |
| 0050239 | West Nile Virus Antibody IgM CSF | 39573-1 |
| 0050394 | HSV 1/2 Antibody Screen IgG, CSF | 13249-8 |
| 0054440 | Measles, Rubeola, Antibody IgG CSF | 9566-1 |
| 0054441 | Measles, Rubeola, Antibody IgM CSF | 21502-0 |
| 0054442 | Mumps Virus Antibody IgG CSF | 13266-2 |
| 0054443 | Mumps Virus Antibody IgM CSF | 13267-0 |
| 0054444 | VZV Antibody IgG CSF | 58755-0 |
| 0054445 | VZV Antibody IgM CSF | 31695-0 |
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
Encephalitis Panel With Reflex to Herpes Simplex Virus Types 1 and 2 Glycoprotein G-Specific Antibodies, IgG, CSF
