Ordering Recommendation

Use to rapidly detect a panel of common viruses, bacteria, and fungi associated with meningitis and encephalitis. Do NOT use as a replacement for CSF bacterial and/or fungal culture and Cryptococcal antigen testing for at-risk patients. A negative result does not exclude a diagnosis of meningitis or encephalitis due to infection.

Mnemonic
MEFAP
Methodology

Qualitative Polymerase Chain Reaction

Performed

Sun-Sat

Reported

Within 24 hours

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

N/A

Collect

CSF

Specimen Preparation

Transfer 0.5 mL CSF to a sterile ARUP Standard Transport Tube (ARUP supply #43115) available online through eSupply using ARUP Connect or contact ARUP Client Services at (800) 522-2787. (Min: 0.25 mL) Do not centrifuge.

Storage/Transport Temperature

Refrigerated

Unacceptable Conditions

N/A

Remarks

N/A

Stability

Ambient: 24 hours; Refrigerated: 1 week; Frozen: Unacceptable

Reference Interval

Not Detected

Interpretive Data

The meningitis/encephalitis panel is NOT a replacement for CSF bacterial and/or fungal culture and Cryptococcal antigen testing for at-risk patients. Non-K1 E. coli serotypes and non-encapsulated strains of Neisseria meningitidis are NOT detected. The panel does NOT differentiate active from latent herpes virus infections. Test results should be interpreted in the context of host factors and other laboratory information.

Compliance Category

FDA

Note

This panel includes Cryptococcus neoformans/gattii, Cytomegalovirus (CMV), Enterovirus, Escherichia coli K1, Haemophilus influenzae, Herpes simplex virus 1(HSV-1), Herpes simplex virus 2(HSV-2), Human herpesvirus 6 (HHV-6), Human parechovirus, Listeria monocytogenes, Neisseria meningitidis, Streptococcus agalactiae, Streptococcus pneumoniae, Varicella-zoster virus (VZV).

Hotline History
N/A
CPT Codes

87483

Components
Component Test Code* Component Chart Name LOINC
2013306 Cytomegalovirus by PCR 82189-2
2013307 Cryptococcus neoformans/gattii by PCR 82181-9
2013308 Escherichia coli K1 by PCR 82182-7
2013309 Enterovirus by PCR 82194-2
2013310 Haemophilus influenzae by PCR 82183-5
2013311 Human herpesvirus 6 by PCR 82192-6
2013312 Herpes simplex virus 1 by PCR 82190-0
2013313 Herpes simplex virus 2 by PCR 82191-8
2013314 Listeria monocytogenes by PCR 82184-3
2013315 Neisseria meningitidis by PCR 82185-0
2013316 Human parechovirus by PCR 82193-4
2013317 Streptococcus agalactiae by PCR 82186-8
2013318 Varicella zoster virus by PCR 82188-4
2013319 Streptococcus pneumoniae by PCR 82187-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Film Array Panel
Meningitis/Encephalitis Panel by PCR