Ordering Recommendation

May aid in the diagnosis of CNS demyelinating disease (including neuromyelitis optica spectrum disorders such as optic neuritis and transverse myelitis) or autoimmune encephalitis (including brainstem encephalitis and acute disseminated encephalomyelitis). 

Serum is the preferred specimen type; refer to Myelin Oligodendrocyte Glycoprotein (MOG) Antibody, IgG by CBA-IFA with Reflex to Titer (3001277) for serum testing.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation


Specimen Preparation

Transfer 0.5 mL CSF to an ARUP standard transport tube. (Min: 0.15 mL)

Storage/Transport Temperature


Unacceptable Conditions

Hemolyzed, contaminated specimens, or severely lipemic specimens.


Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month


Semi-Quantitative Cell-Based Indirect Fluorescent Antibody


Mon, Wed, Fri


1-6 days

Reference Interval

Test Number
Reference Interval
  MOG Ab IgG CBA-IFA Scrn, CSF Less than 1:1

Interpretive Data

Myelin oligodendrocyte glycoprotein (MOG) antibody is found in a subset of patients with neuromyelitis optica spectrum disorders, including optic neuritis and transverse myelitis, brainstem encephalitis, and acute disseminated encephalomyelitis. Persistence of antibody positivity may be associated with a relapsing course; decreasing antibody levels may be associated with therapeutic response. A negative test result does not rule out a diagnosis of CNS demyelinating disease. Low antibody titers have a lower positive predictive value of disease, and should be carefully interpreted in the context of the patient's clinical history, neurologic exam, imaging, and other laboratory findings. Serum is the preferred specimen type, but in some cases patients with MOG-associated disease may be positive only in CSF; CSF positivity may be associated with more severe clinical outcomes.  

This indirect fluorescent antibody assay utilizes full-length MOG transfected cell lines for the detection and semiquantification of MOG IgG antibody.

Compliance Category

Laboratory Developed Test (LDT)


If Myelin Oligodendrocyte Glycoprotein (MOG) Antibody, IgG by IFA with Reflex to Titer, CSF is positive, then a Myelin Oligodendrocyte Glycoprotein (MOG) Antibody Titer, IgG is performed. Additional charges apply.

Hotline History


CPT Codes

86362; if reflexed, add 86256


Component Test Code* Component Chart Name LOINC
3016854 MOG Ab IgG CBA-IFA Scrn, CSF 91543-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Acute disseminated encephalomyelitis
  • ADEM
  • Cell-based assay
  • Cell-binding assay
  • CNS demyelinating disease
  • MOG
  • MOG Antibody
  • MOG Reflex
  • MOG Titer
  • Myelopathy
  • Optic neuritis
  • Pediatric CNS disorders
  • Transverse myelitis
Myelin Oligodendrocyte Glycoprotein (MOG) Antibody, IgG by CBA-IFA With Reflex to Titer, CSF