Myelin Oligodendrocyte Glycoprotein (MOG) Antibody, IgG by CBA-IFA with Reflex to Titer, Serum

3001277
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Example Reports
Detected
None Detected

Ordering Recommendation

Aid in diagnosis of CNS demyelinating disease or autoimmune encephalitis. The presence of myelin oligodendrocyte glycoprotein (MOG) antibody may be associated with neuromyelitis optica spectrum disorders including optic neuritis and transverse myelitis, brainstem encephalitis and acute disseminated encephalomyelitis. May be used in monitoring antibody persistence or treatment response in individuals who are antibody positive.

Mnemonic

MOG SER

Methodology

Semi-Quantitative Cell-Based Indirect Fluorescent Antibody

Performed

Mon,Wed, Fri

Reported

1-6 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum Separator Tube (SST) or Plain Red.

Specimen Preparation

Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Hemolyzed, contaminated, or severely lipemic specimens.

Remarks
Stability

Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month

Reference Interval

Less than 1:10

Interpretive Data

Myelin oligodendrocyte glycoprotein (MOG) antibody is found in a subset of patients with neuromyelitis optica spectrum disorders, including optic neuritis and transverse myelitis, brainstem encephalitis, and acute disseminated encephalomyelitis. Persistence of antibody positivity may be associated with a relapsing course. Decreasing antibody levels may be associated with therapeutic response; therefore, clinical correlation must be strongly considered. A negative test result does not rule out a diagnosis of CNS demyelinating disease or autoimmune encephalitis.

This indirect fluorescent antibody assay utilizes full-length MOG transfected cell lines for the detection and semi-quantification of MOG IgG antibody

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

If Myelin Oligodendrocyte Glycoprotein (MOG) Antibody, IgG by IFA with Reflex to Titer, Serum is positive, then a Myelin Oligodendrocyte Glycoprotein (MOG) Antibody Titer, IgG is performed. Additional charges apply.

Hotline History

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Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
08/15/2022
X
X
N/A

CPT Codes

86362; if reflexed, add 86256

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Components

Component Test Code* Component Chart Name LOINC
3001278 MOG Antibody IgG Screen, Serum 91545-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Acute disseminated encephalomyelitis
  • Cell-based assay
  • Cell-binding assay
  • CNS demyelinating disease
  • MOG
  • MOG Antibody
  • MOG Reflex
  • MOG Titer
  • Myelopathy
  • NMOSD
  • Optic neuritis
  • Pediatric CNS disorders
  • Transverse myelitis
Myelin Oligodendrocyte Glycoprotein (MOG) Antibody, IgG by CBA-IFA with Reflex to Titer, Serum