3001277
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Myelin Oligodendrocyte Glycoprotein (MOG) Antibody, IgG by CBA-IFA With Reflex to Titer, Serum

MOG SER
Example Reports
Detected
None Detected

Ordering Recommendation

Aid in diagnosis of CNS demyelinating disease or autoimmune encephalitis. The presence of myelin oligodendrocyte glycoprotein (MOG) antibody may be associated with neuromyelitis optica spectrum disorders including optic neuritis and transverse myelitis, brainstem encephalitis and acute disseminated encephalomyelitis. May be used in monitoring antibody persistence or treatment response in individuals who are antibody positive.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube (SST) or plain red.

Specimen Preparation

Transfer 1 mL serum to an ARUP standard transport tube. (Min: 0.15 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Hemolyzed, contaminated, or severely lipemic specimens.

Remarks
Stability

Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month

Methodology

Semi-Quantitative Cell-Based Indirect Fluorescent Antibody

Performed

Mon, Wed, Fri

Reported

1-6 days

Reference Interval

Less than 1:10

Interpretive Data

Myelin oligodendrocyte glycoprotein (MOG) antibody is found in a subset of patients with neuromyelitis optica spectrum disorders including optic neuritis and transverse myelitis, brainstem encephalitis, and acute disseminated encephalomyelitis. Persistence of antibody positivity may be associated with a relapsing course. A negative test result does not rule out a diagnosis of CNS demyelinating disease. Results should be interpreted in correlation with the patients clinical history and other laboratory findings.

This indirect fluorescent antibody assay utilizes full-length MOG transfected cell lines for the detection and semiquantification of MOG IgG antibody.

Compliance Category

Laboratory Developed Test (LDT)

Note

If Myelin Oligodendrocyte Glycoprotein (MOG) Antibody, IgG by IFA with Reflex to Titer, Serum is positive, then a Myelin Oligodendrocyte Glycoprotein (MOG) Antibody Titer, IgG is performed. Additional charges apply.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
08/21/2023
X
X
N/A

CPT Codes

86362; if reflexed, add 86256

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Components

Component Test Code* Component Chart Name LOINC
3001278 MOG Ab IgG CBA-IFA Screen, Serum 91545-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • MOG
  • Cell-based assay
  • Cell-binding assay
  • CNS demyelinating disease
  • MOG Antibody
  • MOG Reflex
  • Acute disseminated encephalomyelitis
  • Pediatric CNS disorders
  • Transverse myelitis
  • NMOSD
  • Optic neuritis
  • MOG Titer
  • Myelopathy
Myelin Oligodendrocyte Glycoprotein (MOG) Antibody, IgG by CBA-IFA With Reflex to Titer, Serum