Ordering Recommendation

Aid in diagnosis of CNS demyelinating disease or autoimmune encephalitis. The presence of myelin oligodendrocyte glycoprotein (MOG) antibody may be associated with neuromyelitis optica spectrum disorders including optic neuritis and transverse myelitis, brainstem encephalitis and acute disseminated encephalomyelitis. May be used in monitoring antibody persistence or treatment response in individuals who are antibody positive.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Serum separator tube (SST) or plain red.

Specimen Preparation

Transfer 1 mL serum to an ARUP standard transport tube. (Min: 0.15 mL)

Storage/Transport Temperature


Unacceptable Conditions

Hemolyzed, contaminated, or severely lipemic specimens.


Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month


Semi-Quantitative Cell-Based Indirect Fluorescent Antibody


Mon, Wed, Fri


1-6 days

Reference Interval

Less than 1:10

Interpretive Data

Myelin oligodendrocyte glycoprotein (MOG) antibody is found in a subset of patients with neuromyelitis optica spectrum disorders including optic neuritis and transverse myelitis, brainstem encephalitis, and acute disseminated encephalomyelitis. Persistence of antibody positivity may be associated with a relapsing course. A negative test result does not rule out a diagnosis of CNS demyelinating disease. Results should be interpreted in correlation with the patients clinical history and other laboratory findings.

This indirect fluorescent antibody assay utilizes full-length MOG transfected cell lines for the detection and semiquantification of MOG IgG antibody.

Compliance Category

Laboratory Developed Test (LDT)


If Myelin Oligodendrocyte Glycoprotein (MOG) Antibody, IgG by IFA with Reflex to Titer, Serum is positive, then a Myelin Oligodendrocyte Glycoprotein (MOG) Antibody Titer, IgG is performed. Additional charges apply.

Hotline History


CPT Codes

86362; if reflexed, add 86256


Component Test Code* Component Chart Name LOINC
3001278 MOG Ab IgG CBA-IFA Screen, Serum 91545-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Acute disseminated encephalomyelitis
  • Cell-based assay
  • Cell-binding assay
  • CNS demyelinating disease
  • MOG
  • MOG Antibody
  • MOG Reflex
  • MOG Titer
  • Myelopathy
  • Optic neuritis
  • Pediatric CNS disorders
  • Transverse myelitis
Myelin Oligodendrocyte Glycoprotein (MOG) Antibody, IgG by CBA-IFA With Reflex to Titer, Serum