Connect Sign In
Hereditary Thyroid Cancer Panel, Sequencing and Deletion/Duplication
Ordering Recommendation
Recommended test to confirm a hereditary cause of thyroid cancer in individuals with a personal or family history of thyroid cancer.
To compare this test to other hereditary cancer panels, refer to the ARUP Hereditary Cancer Panel Comparison table.
New York DOH Approval Status
Specimen Required
Lavender or pink (EDTA) or yellow (ACD solution A or B).
New York State Clients: Lavender (EDTA)
Transport 3 mL whole blood. (Min: 2 mL)
New York State Clients: 5 mL (Min: 2 mL)
Refrigerated
Serum or plasma; grossly hemolyzed or frozen specimen; saliva; buccal brush, or swab; FFPE tissue.
Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable
New York State Clients: Ambient: 24 hours; Refrigerated: 1 week; Frozen: Unacceptable
Methodology
Massively Parallel Sequencing / Sequencing
Performed
Varies
Reported
10-15 days
Reference Interval
Refer to report
Interpretive Data
Refer to report.
Laboratory Developed Test (LDT)
Note
GENES TESTED: APC*; DICER1; MEN1*; PRKAR1A; PTEN*; RET; TP53
*One or more exons are not covered by sequencing and/or deletion/duplication analysis for the indicated gene; see Additional Technical Information.
When testing cord blood specimens, the presence of maternal cell contamination (MCC) is possible, which may impact result interpretation. If clinically warranted, testing for MCC is available, at a charge, through ARUP Laboratories.
Hotline History
CPT Codes
81437
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 3005945 | THYCAN Specimen | 66746-9 |
| 3005947 | THYCAN Interp | 50398-7 |
Aliases
- AFAP
- Cowden syndrome
- Familial adenomatous polyposis
- Familial medullary thyroid carcinoma (FMTC)
- Familial thyroid cancer
- FAP
- Li-Fraumeni syndrome
- Medullary carcinoma of the thyroid
- Multiple endocrine neoplasia
