Ordering Recommendation

Aids in the initial evaluation of suspected mast cell activation disorders. A 24-hour urine collection of ≥500 mL is required. If submitting a random urine or 24-hour collection with a total volume of <500mL, refer to Leukotriene E4, Random Urine (3002351).

Mnemonic

LTE 24 URN

Methodology

Quantitative Colorimetry/Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Performed

Varies

Reported

3-9 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Patients taking 5-lipoxygenase inhibitor Zileuton/Zyflo may have decreased concentrations of leukotriene E4 (LTE4). If possible, discontinue 48 hours prior to collection.

Collect

24-hour urine. Refrigerate during collection.

Specimen Preparation

From a well-mixed 24-hour collection transfer 5 mL urine to ARUP Standard Transport Tubes (Min: 2 mL).
Test is not performed at ARUP; separate specimens must be submitted when multiple tests are ordered.

Storage/Transport Temperature

Frozen. Also acceptable: Refrigerated

Unacceptable Conditions
Remarks

Collection duration and urine volume must be provided for testing. Total collection volume must be greater than 500 mL.

Stability

Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 month

Reference Interval

By Report

Interpretive Data



Compliance Category

Performed by non-ARUP Laboratory

Note

Hotline History

N/A

CPT Codes

82542

Components

Component Test Code* Component Chart Name LOINC
3004163 Creatinine, 24 Hour Urine
3004164 Collection Duration:
3004165 Urine Volume:
3004166 Creatinine Concentration, 24 Hour Urine
3004793 Leukotriene E4, 24 Hour Urine 33343-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Cysteinyl Leukotriene
  • LTE4
  • Mastocytosis
  • Systemic mast Cell Activation
Leukotriene E4, 24-Hour Urine

Mayo Clinic Laboratories