Aids in the initial evaluation of suspected mast cell activation disorders. A 24-hour urine collection of ≥500 mL is required. If submitting a random urine or 24-hour collection with a total volume of <500mL, refer to Leukotriene E4, Random Urine (3002351).
Quantitative Colorimetry/Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
New York DOH Approval Status
Patients taking 5-lipoxygenase inhibitor Zileuton/Zyflo may have decreased concentrations of leukotriene E4 (LTE4). If possible, discontinue 48 hours prior to collection.
24-hour urine. Refrigerate during collection.
From a well-mixed 24-hour collection transfer 5 mL urine to ARUP Standard Transport Tubes (Min: 2 mL).
Test is not performed at ARUP; separate specimens must be submitted when multiple tests are ordered.
Frozen. Also acceptable: Refrigerated
Collection duration and urine volume must be provided for testing. Total collection volume must be greater than 500 mL.
Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 month
Performed by non-ARUP Laboratory
|Component Test Code*||Component Chart Name||LOINC|
|3004163||Creatinine, 24 Hour Urine|
|3004166||Creatinine Concentration, 24 Hour Urine|
|3004793||Leukotriene E4, 24 Hour Urine||33343-5|
- Cysteinyl Leukotriene
- Systemic mast Cell Activation
Mayo Clinic Laboratories