Ordering Recommendation

Aid in the initial evaluation of suspected cases of mast cell activation disorders.

Mnemonic

LTE URN

Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Performed

Varies

Reported

3-9 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Patients taking 5-lipoxygenase inhibitor Zileuton/Zyflo may have decreased concentrations of leukotriene E4 (LTE4) if dosage has not been discontinued for 48 hours. If possible, discontinue for 48 hours before testing.

Collect

24-hour urine. Also acceptable Random urine.

Specimen Preparation

Refrigerate specimen during collection. Transfer 4 mL urine to an ARUP Standard Transport Tube. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated. Also acceptable: Frozen.

Unacceptable Conditions
Remarks
Stability

Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 month

Reference Interval

By Report

Interpretive Data



Compliance Category

Performed by non-ARUP Laboratory

Note

Hotline History

N/A

CPT Codes

82542

Components

Component Test Code* Component Chart Name LOINC
3002352 Leukotriene, Urine 33343-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Cysteinyl Leukotriene
  • LTE4
  • Mastocytosis
  • Systemic mast Cell Activation
Leukotriene E4, Urine

Mayo Clinic Laboratories