Consider ordering in individuals with stiff-person syndrome, paraneoplastic encephalomyelitis (PEM), and sensory neuronopathy (SN). May aid in diagnosis of occult tumor, recurrence of tumor, or second tumor. Serum is the preferred specimen; see Amphiphysin Antibody, IgG (2008893).
Mon, Thu, Sat
New York DOH Approval Status
Transfer 1mL CSF to an ARUP Standard Transport Tube. (Min: 0.60 mL)
Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month
Amphiphysin antibody is present in about 5 percent of patients with stiff-person syndrome and is found variably in other causes of paraneoplastic neurological syndrome (PNS). Amphiphysin antibody is mainly associated with small cell lung cancer and breast tumors.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA-certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
|Component Test Code*||Component Chart Name||LOINC|
|3004511||Amphiphysin Antibody, CSF||57750-2|
- Progressive encephalomyelitis
- Sensory neuropathy