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Amphiphysin Antibody, IgG
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Ordering Recommendation
Consider ordering in individuals with stiff-person syndrome, paraneoplastic encephalomyelitis (PEM), and sensory neuronopathy (SN). May aid in diagnosis of occult tumor, recurrence of tumor, or second tumor.
Mnemonic
Methodology
Qualitative Immunoblot
Performed
Mon, Thu, Sat
Reported
1-4 days
New York DOH Approval Status
Specimen Required
Serum separator tube.
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.30 mL)
Refrigerated.
Plasma. Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month
Reference Interval
Negative
Interpretive Data
Amphiphysin antibody is present in about 5 percent of patients with stiff-person syndrome and is found variably in other causes of paraneoplastic neurological syndrome (PNS). Amphiphysin antibody is mainly associated with small-cell lung cancer and breast tumors.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
Hotline History
CPT Codes
84182
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0051709 | Neuronal Antibody (Amphiphysin) | 94385-2 |
Aliases
- PERM
- Progressive encephalomyelitis
- Sensory neuropathy
- Stiff-man
- Stiff-person
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