Ordering Recommendation

Recommended diagnostic or predictive test for APC-associated polyposis conditions (familial adenomatous polyposis [FAP], attenuated FAP, gastric adenocarcinoma and proximal polyposis of the stomach [GAPPS]) and MUTYH-associated polyposis (MAP). Testing minors for adult-onset conditions is not recommended; testing will not be performed in minors without prior approval. For additional information, please contact an ARUP genetic counselor at 800-242-2787 ext. 2141.

To compare this test to other hereditary cancer panels, refer to the Hereditary Cancer Panel Comparison table.

New York DOH Approval Status

Testing is not New York state approved. Specimens from New York clients will be sent out to a New York state-approved laboratory.

Specimen Required

Patient Preparation

Lavender or Pink (EDTA) or Yellow (ACD Solution A or B).
New York State Clients: Lavender (EDTA)

Specimen Preparation

Transport 3 mL whole blood. (Min: 3 mL)
New York State Clients: 5 mL (Min: 3 mL)

Storage/Transport Temperature


Unacceptable Conditions

Serum or plasma; grossly hemolyzed or frozen specimens; saliva; buccal brush or swab, FFPE tissue.


Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable


Massively Parallel Sequencing




10-15 days

Reference Interval

By report

Interpretive Data

Refer to report

Compliance Category

Laboratory Developed Test (LDT)


Genes Tested: APC (NM_000038, NM_001127511 Exon 1b only), MUTYH (NM_001128425)

Hotline History


CPT Codes

81201; 81203; 81406; 81479


Component Test Code* Component Chart Name LOINC
3004408 APCMYH Specimen 66746-9
3004409 APCMYH Interp 35474-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • AFAP
  • familial adenomatous polyposis
  • FAP
  • Gardner syndrome
  • MAP
  • MYH
  • Turcot syndrome
APC- and MUTYH-Associated Polyposis Panel, Sequencing and Deletion/Duplication