APC- and MUTYH-Associated Polyposis Panel, Sequencing and Deletion/Duplication

3004407
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Example Reports
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Additional Technical Information

Ordering Recommendation

Recommended diagnostic or predictive test for APC-associated polyposis conditions (familial adenomatous polyposis [FAP], attenuated FAP, gastric adenocarcinoma and proximal polyposis of the stomach [GAPPS]) and MUTYH-associated polyposis (MAP). Testing minors for adult-onset conditions is not recommended; testing will not be performed on minors without prior approval. For additional information, please contact an ARUP genetic counselor at 800-242-2787 ext. 2141.

To compare this test to other hereditary cancer panels, refer to the Hereditary Cancer Panel Comparison table.

Mnemonic

APCMYH NGS

Methodology

Massively Parallel Sequencing

Performed

Varies

Reported

3 weeks

New York DOH Approval Status

Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.

Specimen Required

Patient Preparation
Collect

Lavender or Pink (EDTA) or Yellow (ACD Solution A or B).

Specimen Preparation

Transport 3 mL whole blood. (Min: 3 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Serum or plasma; grossly hemolyzed or frozen specimens; saliva; buccal brush or swab, FFPE tissue.

Remarks
Stability

Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable

Reference Interval

By report

Interpretive Data

Refer to report

Compliance Category

Laboratory Developed Test (LDT)

Note

Genes Tested: APC (NM_000038, NM_001127511 Exon 1b only), MUTYH (NM_001128425)

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
02/22/2022
X
N/A

CPT Codes

81201; 81203; 81406; 81479

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Components

Component Test Code* Component Chart Name LOINC
3004408 APCMYH Specimen 66746-9
3004409 APCMYH Interp 35474-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • AFAP
  • familial adenomatous polyposis
  • FAP
  • GAPPS
  • Gardner syndrome
  • MAP
  • MYH
  • Turcot syndrome
APC- and MUTYH-Associated Polyposis Panel, Sequencing and Deletion/Duplication