Ordering Recommendation

Recommended diagnostic or predictive test for APC-associated polyposis conditions (familial adenomatous polyposis [FAP], attenuated FAP, gastric adenocarcinoma and proximal polyposis of the stomach [GAPPS]) and MUTYH-associated polyposis (MAP). Testing minors for adult-onset conditions is not recommended; testing will not be performed in minors without prior approval. For additional information, please contact an ARUP genetic counselor at 800-242-2787 ext. 2141.

To compare this test to other hereditary cancer panels, refer to the Hereditary Cancer Panel Comparison table.


Massively Parallel Sequencing




10-15 days

New York DOH Approval Status

Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.

Specimen Required

Patient Preparation

Lavender or Pink (EDTA) or Yellow (ACD Solution A or B).

Specimen Preparation

Transport 3 mL whole blood. (Min: 3 mL)

Storage/Transport Temperature


Unacceptable Conditions

Serum or plasma; grossly hemolyzed or frozen specimens; saliva; buccal brush or swab, FFPE tissue.


Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable

Reference Interval

By report

Interpretive Data

Refer to report

Compliance Category

Laboratory Developed Test (LDT)


Genes Tested: APC (NM_000038, NM_001127511 Exon 1b only), MUTYH (NM_001128425)

Hotline History


CPT Codes

81201; 81203; 81406; 81479


Component Test Code* Component Chart Name LOINC
3004408 APCMYH Specimen 66746-9
3004409 APCMYH Interp 35474-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • AFAP
  • familial adenomatous polyposis
  • FAP
  • Gardner syndrome
  • MAP
  • MYH
  • Turcot syndrome
APC- and MUTYH-Associated Polyposis Panel, Sequencing and Deletion/Duplication