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Coccidioides Ab by CF & ID, CSF
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Ordering Recommendation
Aids in diagnosis of coccidioidal meningitis (Valley fever).
Mnemonic
Methodology
Semi-Quantitative Complement Fixation/Qualitative Immunodiffusion
Performed
Sun-Sat
Reported
2-6 days
New York DOH Approval Status
Specimen Required
CSF.
Transfer 2.5 mL CSF to an ARUP Standard Transport Tube. (Min: 1 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens.
Refrigerated.
Other body fluids. Contaminated, hemolyzed, xanthochromic, or severely lipemic specimens.
Mark specimens plainly as "acute" or "convalescent."
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval
| Test Number | Components | Reference Interval |
|---|---|---|
| 3000064 | Coccidioides by Immunodiffusion, CSF | None detected. |
| 0050711 | Coccidioides Ab by CF, CSF | Less than 1:2 |
Interpretive Data
Refer to report.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Modified FDA
Note
For Coccidioides, immunodiffusion (ID) measures IgM antibody, while complement fixation (CF) measures both IgG and IgM. ELISA tests can be used to detect both coccidioidal IgG and IgM antibodies. While elevated single antibody titers may be diagnostic, paired specimens are preferred. Acute and convalescent specimens (drawn at least 21 days apart) showing a fourfold or greater rise in titer are diagnostic.
Negative fungal serology does not rule out the possibility of current infection.
Hotline History
Hotline History
CPT Codes
86635 x2
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0050711 | Coccidioides Ab by CF, CSF | 13917-0 |
| 3000064 | Coccidioides by Immunodiffusion, CSF | 21209-2 |
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