Ordering Recommendation

Comprehensive test to aid in the diagnosis of coccidioidal meningitis. Includes testing by immunoassay (IgM and IgG), complement fixation, and immunodiffusion.

Mnemonic

COCCIABCSF

Methodology

Complement Fixation/Immunodiffusion/Enzyme-Linked Immunosorbent Assay (ELISA)

Performed

Sun-Sat

Reported

3-6 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

CSF.

Specimen Preparation

Transfer 2 mL CSF to an ARUP Standard Transport Tube. (Min: 1 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens.

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Other body fluids. Contaminated, hemolyzed, xanthochromic, or severely lipemic specimens.

Remarks

Mark specimens plainly as "acute" or "convalescent".

Stability

Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

Effective May 16, 2022

Test Number
Components
Reference Interval
  Coccidioides by Immunodiffusion, CSF Not detected.
3000059 Coccidioides Antibodies by Complement Fixation, CSF Less than 1:2
3000055 Coccidioides Antibodies IgG by Immunoassay, CSF
0.2 IV or less Negative - No significant level of Coccidioides IgG antibody detected.
0.3 IV or greater Positive - Presence of IgG antibody to Coccidioides detected, suggestive of current or past infection.

3000056 Coccidioides Antibodies IgM by Immunoassay, CSF
0.2 IV or less Negative - No significant level of Coccidioides IgM antibody detected.
0.3 IV or greater Positive - Presence of IgM antibody to Coccidioides detected, suggestive of current or recent infection.

Interpretive Data

Refer to report.

Compliance Category

Modified FDA

Note

The immunoassay component of this test uses recombinant and native Coccidioides antigens, including the CF and TP antigens.
The immunodiffusion component of this test uses culture filtrates of Coccidioides immitis and includes CF and TP antigens.

Hotline History

N/A

CPT Codes

86635 x4

Components

Component Test Code* Component Chart Name LOINC
0050711 Coccidioides Ab by CF, CSF 13917-0
3000062 Coccidioides Antibody IgG ELISA, CSF 16638-9
3000063 Coccidioides Antibody IgM ELISA, CSF 16639-7
3000064 Coccidioides by Immunodiffusion, CSF 21209-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Coccidioides immitis
  • Coccidioidomycosis
  • Valley fever
Coccidioides Antibodies Panel, CSF