Paraneoplastic Reflexive Panel
Serum test to aid in the diagnosis of paraneoplastic neurologic syndromes.
This test only evaluates for the presence of high-risk paraneoplastic antibodies, independent of neurologic phenotype. Targeted phenotype-specific panels are preferred for the evaluation of autoimmune neurologic disease. Refer to the ARUP Autoimmune Neurology Panel Components tables for phenotype-specific test options.
Testing in both serum and CSF is recommended to maximize diagnostic yield; refer to Paraneoplastic Reflexive Panel, CSF (3004517) for CSF testing.
New York DOH Approval Status
Serum Separator Tube (SST)
Separate from cells ASAP or within 2 hours of collection. Transfer 3 mL serum aliquot to an ARUP Standard Transport Tube. (Min: 1.0 mL)
Contaminated, heat-inactivated, hemolyzed, or lipemic specimens
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month
Semi-Quantitative Cell-Based Indirect Fluorescent Antibody/Qualitative Immunoblot
|Neuronal Antibody (Amphiphysin)||Negative|
|Purkinje Cell/Neuronal Nuclear IgG Scrn||None Detected|
|CV2.1 Ab IgG CBA-IFA Screen, Serum||Less than 1:10|
|SOX1 Antibody, IgG by Immunoblot, Serum||Negative|
Refer to report
Laboratory Developed Test (LDT)
Purkinje Cell (PCCA) antibody and Neuronal Nuclear (ANNA) antibody IgG are screened by IFA. If the IFA screen is indeterminate, then a Neuronal Nuclear Antibodies (Hu, Ri, Yo, Tr/DNER) IgG by Immunoblot will be added. If the IFA screen is positive at 1:10 or greater, then a PCCA/ANNA antibodies titer and Neuronal Nuclear Antibodies (Hu, Ri, Yo, Tr/DNER) IgG by Immunoblot will be added. Additional charges apply. If CV2.1 Antibody IgG Screen by IFA is positive, then CV2.1 Antibody IgG Titer by IFA will be added. Additional charges apply.
86255 x2; 84182 x2; if reflexed add 86256 and/or 84182 x4; if reflexed add 86256
|Component Test Code*||Component Chart Name||LOINC|
|0051709||Neuronal Antibody (Amphiphysin)||94385-2|
|2007962||Purkinje Cell/Neuronal Nuclear IgG Scrn||61177-2|
|2013959||CV2.1 Ab IgG CBA-IFA Screen, Serum||72504-4|
|3002903||SOX1 Antibody, IgG by Immunoblot, Serum||82444-1|