Chromogenic Factor VIII, Activity
Ordering Recommendation
Useful in combination with Factor VIII, Activity (0030095) for the initial diagnosis of mild hemophilia A. May also be used to measure factor VIII activity in the presence of a lupus anticoagulant. Monitor certain extended half-life factor VIII replacement products and measure native factor VIII or factor VIII concentrates in patients on emicizumab (Hemlibra).
Methodology
Chromogenic Assay
Performed
Mon, Wed, Fri
Reported
1-4 days
New York DOH Approval Status
Specimen Required
Light Blue (Sodium Citrate). Special Specimen Collection and Handling Hemostasis/Thrombosis Specimens guide located at https://www.aruplab.com/Specimen-Handling/SpecialSpecimenCollection/Hemostasis-Thrombosis.pdf
Transfer 1 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 0.8 mL)
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Serum or EDTA plasma. Clotted or hemolyzed specimens.
Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20° C: 3 months; Frozen at -70° C: 6 months
Reference Interval
Age | Reference Interval |
0-6 years | 56-191 percent |
7-9 years | 76-199 percent |
10-11 years | 80-209 percent |
12-13 years | 72-198 percent |
14-15 years | 69-237 percent |
16-17 years | 63-221 percent |
18 years and older | 56-191 percent |
Interpretive Data
Information on the clinical uses of chromogenic FVIII activity testing can be found at arupconsult.com.
Laboratory Developed Test (LDT)
Note
Hotline History
CPT Codes
85240
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
3002344 | Chromogenic Factor VIII, Activity | 49865-9 |
Aliases
- ADYNOVATE, AFSTYLA, ELOCTATE
- AHF chromogenic
- Antihemophilic Factor (AHF) chromogenic
- Coagulation Factor VIII Chromogenic activity assay, plasma
- Factor VIII activity, chromogenic
- Factor VIII chromogenic assay
- Factor VIII:C chromogenic
- Hemlibra; emicizumab, extended half-life factor VIII products