Ordering Recommendation
Use to screen for mast cell activation disorders. A 24-hour urine collection of ≥500 mL is required. If submitting a random urine or 24-hour collection with a total volume of <500 mL, refer to 2,3 Dinor-11Beta-Prostaglandin F2 Alpha, Random Urine (3004160).
Mnemonic
Methodology
Quantitative Colorimetry/Liquid Chromatography-Tandem Mass Spectrometry
Performed
Varies
Reported
3-11 days
New York DOH Approval Status
Specimen Required
Patients taking aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) may have decreased concentrations of prostaglandin F2 alpha. If possible, discontinue for 2 weeks or 72 hours, respectively, prior to specimen collection.
24-hour urine. Refrigerate during collection.
From a well-mixed 24-hour collection transfer 5 mL urine to ARUP standard transport tubes. (Min: 4 mL)
Test is not performed at ARUP; separate specimens must be submitted when multiple tests are ordered.
Refrigerated. Also acceptable: Frozen.
Collection duration and urine volume must be provided for testing. Total collection volume must be greater than 500 mL.
Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: 1 month
Reference Interval
By Report
Interpretive Data
Performed by non-ARUP Laboratory
Note
Elevated levels of 2,3-dinor-11beta-prostaglandin F2 alpha (2,3 BPG) in urine are not specific for systemic mast cell disease and may be found in patients with angioedema, diffuse urticaria, or myeloproliferative diseases in the absence of diffuse mast cell proliferation.
Hotline History
Hotline History
CPT Codes
84150
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
3002338 | 2,3 Dinor-11Beta-Prostaglandin F2a, 24 U | 94381-1 |
3004163 | Creatinine, 24 Hour Urine | 2162-6 |
3004164 | Collection Duration: | 13362-9 |
3004165 | Urine Volume: | 3167-4 |
3004166 | Creatinine Concentration, 24 Hour Urine | 20624-3 |
Aliases
- 11 Beta-Prostaglandin F2 Alpha
- 11BPG
- 2, 3 11 Beta-Prostaglandin F2 Alpha
- 23BPG
- BPG2
- Mastocytosis
- Prostaglandin
Mayo Clinic Laboratories