Use to screen for mast cell activation disorders. A 24-hour urine collection of ≥500 mL is required. If submitting a random urine or 24-hour collection with a total volume of <500 mL, refer to 2,3 Dinor-11Beta-Prostaglandin F2 Alpha, Random Urine (3004160).
Quantitative Colorimetry/Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
New York DOH Approval Status
Patients taking aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) may have decreased concentrations of prostaglandin F2 alpha. If possible, discontinue for 2 weeks or 72 hours, respectively, prior to specimen collection.
24-hour urine. Refrigerate during collection.
From a well-mixed 24-hour collection transfer 5 mL urine to ARUP Standard Transport Tubes. (Min: 4 mL)
Test is not performed at ARUP; separate specimens must be submitted when multiple tests are ordered.
Refrigerated. Also acceptable: Frozen.
Collection duration and urine volume must be provided for testing. Total collection volume must be greater than 500 mL.
Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: 1 month
Performed by non-ARUP Laboratory
Elevated levels of 2,3-dinor-11beta-prostaglandin F2 alpha (2,3 BPG) in urine are not specific for systemic mast cell disease and may be found in patients with angioedema, diffuse urticaria, or myeloproliferative diseases in the absence of diffuse mast cell proliferation.
|Component Test Code*||Component Chart Name||LOINC|
|3002338||2,3 Dinor-11Beta-Prostaglandin F2a, 24 U||94381-1|
|3004163||Creatinine, 24 Hour Urine|
|3004166||Creatinine Concentration, 24 Hour Urine|
- 11 Beta-Prostaglandin F2 Alpha
- 2, 3 11 Beta-Prostaglandin F2 Alpha
Mayo Clinic Laboratories