Ordering Recommendation

Use to screen for mast cell activation disorders. A 24-hour urine collection of 300 mL or greater is required. If submitting a random urine or 24-hour collection with a total volume of less than 300 mL, refer to 2,3 Dinor-11Beta-Prostaglandin F2 Alpha, Random Urine (3004160).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Patients taking aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) may have decreased concentrations of prostaglandin F2 alpha. If possible, discontinue for 2 weeks or 72 hours, respectively, prior to specimen collection.


24-hour urine. Refrigerate during collection.

Specimen Preparation

From a well-mixed 24-hour collection transfer 5 mL urine to ARUP standard transport tubes. (Min: 4 mL)
Test is not performed at ARUP; separate specimens must be submitted when multiple tests are ordered.

Storage/Transport Temperature

Refrigerated. Also acceptable: Frozen.

Unacceptable Conditions

Collection duration and urine volume must be provided for testing. Total collection volume must be greater than 300 mL.


Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: 1 month


Quantitative Colorimetry/High Performance Liquid Chromatography-Tandem Mass Spectrometry




3-11 days

Reference Interval

By Report

Interpretive Data

Compliance Category

Performed by non-ARUP Laboratory


Elevated levels of 2,3-dinor-11beta-prostaglandin F2 alpha (2,3 BPG) in urine are not specific for systemic mast cell disease and may be found in patients with angioedema, diffuse urticaria, or myeloproliferative diseases in the absence of diffuse mast cell proliferation.

Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
3002338 2,3 Dinor-11Beta-Prostaglandin F2a, 24 U 94381-1
3004163 Creatinine, 24 Hour Urine 2162-6
3004166 Creatinine Concentration, 24 Hour Urine 20624-3
3016697 Collection Duration - 13362-9
3016698 Urine Volume - 3167-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • 11 Beta-Prostaglandin F2 Alpha
  • 11BPG
  • 2, 3 11 Beta-Prostaglandin F2 Alpha
  • 23BPG
  • BPG2
  • Mastocytosis
  • Prostaglandin
2,3 Dinor-11Beta-Prostaglandin F2 Alpha, 24-Hour Urine

Mayo Clinic Laboratories