Aid in the monitoring of patients with urinary monoclonal proteins (Bence Jones protein).
Qualitative Immunofixation Electrophoresis/Quantitative Immunoturbidimetry
Sun-Sat
1-5 days
24-hour urine. Refrigerate during collection. Also acceptable: Random urine specimens and urine supernate.
Transfer two 4 mL aliquots from a well-mixed 24-hour collection to individual ARUP Standard Transport Tubes. (Min: 4 mL)
Refrigerated.
Record total volume and collection time interval on transport tube and test request form.
Ambient: Unacceptable; Refrigerated: 3 weeks; Frozen: 6 months
Test Number |
Components |
Reference Interval |
---|---|---|
Total Protein | Less than 150 mg/d | |
Free Urinary Kappa Light Chains | 0.00 - 32.90 mg/L | |
Free Urinary Kappa Excretion/Day | By report | |
Free Urinary Lambda Light Chain | 0.00 - 3.79 mg/L | |
Free Urinary Lambda Excretion/Day | By report | |
IFE Interpretation | By report |
Results of urine free light chain testing can be used to monitor disease progression or response to therapy in patients for whom urine electrophoresis is unable to provide reliable Bence Jones Protein quantification. The results of urine kappa and lambda free light chain quantitative values may be misleading in specimens with high levels of urinary polyclonal free light chains, and absent Bence Jones protein by immunofixation; therefore correlation with urine immunofixation is required to identify inconsistent results.
Total urinary protein is determined turbidimetrically by adding the albumin and kappa and/or lambda light chains. This value may not agree with the total protein as determined by chemical methods, which characteristically underestimates urinary light chains.
FDA
Hotline History
84156; 86335; 83520 x2
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0050565 | Total Protein | 2889-4 |
0050683 | Free Urinary Kappa Light Chains | 38176-4 |
0050684 | Free Urinary Kappa Excretion/Day | 38177-2 |
0050685 | Free Urinary Lambda Light Chain | 38178-0 |
0050686 | Free Urinary Lambda Excretion/Day | 38169-9 |
0050688 | IFE Interpretation | 49277-7 |
0097110 | Total Volume | 19153-6 |
0097111 | Hours Collected | 30211-7 |
- Free Urinary Kappa Light Chains
- Free Urinary Kappa/Lambda Ratio
- Free Urinary Lambda Light Chain
- IFE
- IFE urine
- Immunofixation Electrophoresis, urine
- Monoclonal protein detection and quantitation, urine
- UPEP
- Urinary Light Chains