Time Sensitive


Oncology Test Request Form Recommended (ARUP form #43099)

Ordering Recommendation

Aids in risk stratification of individuals with multiple myeloma. Recommended at initial diagnosis and in standard or low-risk individuals at time of disease progression.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Non-diluted bone marrow collected in a heparinized syringe. Also acceptable: Green (sodium heparin).

Specimen Preparation

Transfer 3 mL bone marrow to a green (sodium heparin) (Min: 1 mL). OR transport 5 mL whole blood (Min: 2 mL).

Storage/Transport Temperature

Room temperature.

Unacceptable Conditions

Frozen specimens. Paraffin-embedded specimens. Clotted specimens.


Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable


Fluorescence in situ Hybridization (FISH)




5-14 days

Reference Interval

By report

Interpretive Data

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Analyte Specific Reagent (ASR)


Fluorescence in situ hybridization (FISH) panel is performed on CD138+ sorted cells (assuming specimen is sufficient for sorting) for multiple myeloma prognosis-specific genomic abnormalities: 1q (CKS1B) gain/amplification/17p (TP53) loss/deletion, t(4;14) (IGH/FGFR3 and MMSET fusion), +9/9p (JAK2) enumeration, t(11;14) (IGH/CCND1 fusion and/or +11), t(14;16) (IGH/MAF fusion), t(14;20) (IGH/MAFB fusion).

When this test is ordered in conjunction with a chromosome analysis, specimen prioritization will be given to FISH for the sorting of CD138+ cells. This could impact the successful completion of the chromosome analysis.   

If sorting fails to yield sufficient CD138+ cells, testing will be performed using unsorted cells, if available.

A processing fee will be charged if this procedure is canceled at the client's request, after the test has been set up, or if the specimen integrity is inadequate to allow a complete analysis.

This test must be ordered using Oncology test request form #43099 or through your ARUP interface.
Contact ARUP Genetics Processing for other specimen types or information and specific collection and transportation instructions.

Hotline History


CPT Codes

88271 x7; 88275 x7


Component Test Code* Component Chart Name LOINC
0092617 Multiple Myeloma Panel by FISH 57802-1
3002592 EER Multiple Myeloma Panel by FISH
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • CD138
  • MGUS
  • MM
  • multiple myeloma
  • PCN
  • Plasma cell neoplasms
Multiple Myeloma Panel by FISH