3002063
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Multiple Myeloma Panel by FISH

FISHMMP
Example Reports
Abnormal
Enhanced Report
Normal

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Time Sensitive

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Oncology Test Request Form Recommended (ARUP form #43099)

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Additional Technical Information

Ordering Recommendation

Aids in risk stratification of individuals with plasma cell neoplasms (monoclonal gammopathy of unknown significance [MGUS], smoldering multiple myeloma [SMM], multiple myeloma [MM]). Recommended at initial diagnosis and/or at disease progression. Refer to companion test FISH, Interphase, CD138+ Cells (3002737) for custom FISH probe ordering to monitor for a previously identified clone.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Nondiluted bone marrow collected in a heparinized syringe. Also acceptable: whole blood collected in green (sodium heparin).

Specimen Preparation

Transfer 3 mL bone marrow to a green (sodium heparin) (Min: 1 mL). OR transport 5 mL whole blood (green, sodium heparin) (Min: 2 mL).

Additional specimen (recommend 2 mL) is required if concurrent testing (chromosome analysis and/or genomic microarray) is ordered due to the need to perform CD138+ cell enrichment process.

Storage/Transport Temperature

Room temperature.

Unacceptable Conditions

Frozen specimens. Paraffin-embedded specimens. Clotted specimens.

Remarks
Stability

Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable

Methodology

Fluorescence in situ Hybridization (FISH)

Performed

Sun-Sat

Reported

5-14 days

Reference Interval

By report

Interpretive Data



Compliance Category

Analyte Specific Reagent (ASR)

Note

Fluorescence in situ hybridization (FISH) panel is performed on CD138+ enriched cells (assuming specimen is sufficient for enrichment) for multiple myeloma prognosis-specific genomic abnormalities: 1p (CDKN2C loss/deletion)/1q (CKS1B gain/amplification), 17p (TP53 loss/deletion)/ 17q (NF1) control, t(4;14) (IGH/FGFR3 or NSD2 (MMSET) fusion), t(11;14) (IGH/CCND1 fusion and/or +11), t(14;16) (IGH/MAF fusion), t(14;20) (IGH/MAFB fusion).

When this test is ordered in conjunction with a chromosome analysis, and/or genomic microarray, specimen prioritization for low cellularity samples will be given to FISH>microarray>karyotype due to the need for  CD138+ cell enrichment prior to FISH and microarray testing. This could impact successful completion of lower priority tests.

If enrichment fails to yield sufficient CD138+ cells, testing will be performed using unenriched cells, if available.

A processing fee will be charged if this procedure is canceled at the client's request, after the test has been set up, or if the specimen integrity is inadequate to allow a complete analysis.

This test must be ordered using Oncology test request form #43099 or through your ARUP interface.

Contact ARUP Genetics Processing for other specimen types or information and specific collection and transportation instructions.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
05/20/2024
X
X
N/A

CPT Codes

88271 x7; 88275 x7

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Components

Component Test Code* Component Chart Name LOINC
0092617 Multiple Myeloma Panel by FISH 57802-1
3002592 EER Multiple Myeloma Panel by FISH
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • CD138
  • MGUS
  • PCN
  • MM
  • multiple myeloma
  • Plasma cell neoplasms
  • SMM
Multiple Myeloma Panel by FISH