Time Sensitive


Oncology Test Request Form Recommended (ARUP form #43099)

Ordering Recommendation

Aids in risk stratification of individuals with plasma cell neoplasms (monoclonal gammopathy of unknown significance [MGUS], smoldering multiple myeloma [SMM], multiple myeloma [MM]). Recommended at initial diagnosis and/or at disease progression. Refer to companion test FISH, Interphase, CD138+ Cells (3002737) for custom FISH probe ordering to monitor for a previously identified clone. 

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Nondiluted bone marrow collected in a heparinized syringe. Also acceptable: whole blood collected in green (sodium heparin).

Specimen Preparation

Transfer 3 mL bone marrow to a green (sodium heparin) (Min: 1 mL). OR transport 5 mL whole blood (green, sodium heparin) (Min: 2 mL).

Additional specimen (recommend 2 mL) is required if concurrent testing (chromosome analysis and/or genomic microarray) is ordered due to the need to perform CD138+ cell enrichment process.

Storage/Transport Temperature

Room temperature.

Unacceptable Conditions

Frozen specimens. Paraffin-embedded specimens. Clotted specimens.


Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable


Fluorescence in situ Hybridization (FISH)




5-14 days

Reference Interval

By report

Interpretive Data

Compliance Category

Analyte Specific Reagent (ASR)


Fluorescence in situ hybridization (FISH) panel is performed on CD138+ enriched cells (assuming specimen is sufficient for enrichment) for multiple myeloma prognosis-specific genomic abnormalities: 1p (CDKN2C loss/deletion)/1q (CKS1B gain/amplification), 17p (TP53 loss/deletion)/ 17q (NF1) control, t(4;14) (IGH/FGFR3 or NSD2 (MMSET) fusion), t(11;14) (IGH/CCND1 fusion and/or +11), t(14;16) (IGH/MAF fusion), t(14;20) (IGH/MAFB fusion).

When this test is ordered in conjunction with a chromosome analysis, and/or genomic microarray, specimen prioritization for low cellularity samples will be given to FISH>microarray>karyotype due to the need for  CD138+ cell enrichment prior to FISH and microarray testing. This could impact successful completion of lower priority tests.

If enrichment fails to yield sufficient CD138+ cells, testing will be performed using unenriched cells, if available.

A processing fee will be charged if this procedure is canceled at the client's request, after the test has been set up, or if the specimen integrity is inadequate to allow a complete analysis.

This test must be ordered using Oncology test request form #43099 or through your ARUP interface.

Contact ARUP Genetics Processing for other specimen types or information and specific collection and transportation instructions.

Hotline History


CPT Codes

88271 x7; 88275 x7


Component Test Code* Component Chart Name LOINC
0092617 Multiple Myeloma Panel by FISH 57802-1
3002592 EER Multiple Myeloma Panel by FISH
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • CD138
  • MGUS
  • MM
  • multiple myeloma
  • PCN
  • Plasma cell neoplasms
  • SMM
Multiple Myeloma Panel by FISH