Multiple Myeloma Panel by FISH (Temporary Delay as of 09/17/21 - no referral available)
Aids in risk stratification of individuals with multiple myeloma. Recommended at initial diagnosis and in standard or low-risk individuals at time of disease progression.
Fluorescence in situ Hybridization
New York DOH Approval Status
Non-diluted bone marrow collected in a heparinized syringe. Also acceptable: Green (sodium heparin).
Transfer 3 mL bone marrow to a green (sodium heparin) (Min: 1 mL). OR transport 5 mL whole blood (Min: 2 mL).
Frozen specimens. Paraffin-embedded specimens. Clotted specimens.
Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Analyte Specific Reagent (ASR)
Fluorescence in situ hybridization (FISH) panel is performed on CD138+ sorted cells (assuming specimen is sufficient for sorting) for multiple myeloma prognosis-specific genomic abnormalities: 1q (CKS1B) gain/amplification/17p (TP53) loss/deletion, t(4;14) (IGH/FGFR3 and MMSET fusion), +9/9p (JAK2) enumeration, t(11;14) (IGH/CCND1 fusion and/or +11), t(14;16) (IGH/MAF fusion), t(14;20) (IGH/MAFB fusion).
When this test is ordered in conjunction with a chromosome analysis, specimen prioritization will be given to FISH for the sorting of CD138+ cells. This could impact the successful completion of the chromosome analysis.
If sorting fails to yield sufficient CD138+ cells, testing will be performed using unsorted cells, if available.
A processing fee will be charged if this procedure is canceled at the client's request, after the test has been set up, or if the specimen integrity is inadequate to allow a complete analysis.
This test must be ordered using Oncology test request form #43099 or through your ARUP interface.
Contact ARUP Genetics Processing for other specimen types or information and specific collection and transportation instructions.
88271 x7; 88275 x7
|Component Test Code*||Component Chart Name||LOINC|
|0092617||Multiple Myeloma Panel by FISH||57802-1|
|3002592||EER Multiple Myeloma Panel by FISH|
- multiple myeloma
- Plasma cell neoplasms