Time Sensitive


Oncology Test Request Form Recommended (ARUP form #43099)
Ordering Recommendation

Aids in risk stratification of individuals with multiple myeloma. Recommended at initial diagnosis and in standard or low-risk individuals at time of disease progression.


Fluorescence in situ Hybridization




5-14 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Non-diluted bone marrow collected in a heparinized syringe. Also acceptable: Green (sodium heparin).

Specimen Preparation

Transfer 3 mL bone marrow to a green (sodium heparin) (Min: 1 mL). OR transport 5 mL whole blood (Min: 2 mL).

Storage/Transport Temperature

Room temperature.

Unacceptable Conditions

Frozen specimens. Paraffin-embedded specimens. Clotted specimens.


Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable

Reference Interval

By report

Interpretive Data

Compliance Category

Analyte Specific Reagent (ASR)


Fluorescence in situ hybridization (FISH) panel is performed on CD138+ sorted cells (assuming specimen is sufficient for sorting) for multiple myeloma prognosis-specific genomic abnormalities: 1q (CKS1B) gain/amplification/17p (TP53) loss/deletion, t(4;14) (IGH/FGFR3 and MMSET fusion)/+9/9q (ASS1) trisomy/gain, t(11;14) (IGH/CCND1 fusion and/or +11), t(14;16) (IGH/MAF fusion), t(14;20) (IGH/MAFB fusion).

When this test is ordered in conjunction with a chromosome analysis, specimen prioritization will be given to FISH for the sorting of CD138+ cells. This could impact the successful completion of the chromosome analysis.   

If sorting fails to yield sufficient CD138+ cells, testing will be performed using unsorted cells, if available.

A processing fee will be charged if this procedure is canceled at the client's request, after the test has been set up, or if the specimen integrity is inadequate to allow a complete analysis.

This test must be ordered using Oncology test request form #43099 or through your ARUP interface.
Contact ARUP Genetics Processing for other specimen types or information and specific collection and transportation instructions.

Hotline History
CPT Codes

88271 x7; 88275 x7; 88291

Component Test Code* Component Chart Name LOINC
0092617 Multiple Myeloma Panel by FISH 57802-1
3002592 EER Multiple Myeloma Panel by FISH
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • CD138
  • MGUS
  • MM
  • multiple myeloma
  • PCN
  • Plasma cell neoplasms
Multiple Myeloma Panel by FISH