Ordering Recommendation

Use to detect low-risk HPV subtypes. Preferred test to determine potential cancer risk is Human Papillomavirus (HPV) High Risk by in situ Hybridization, Paraffin (3002008).

Mnemonic
HPVLR ISH
Methodology

In situ Hybridization

Performed

Mon-Thu

Reported

2-5 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Tissue.

Specimen Preparation

Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Transport tissue block or 5 unstained positively charged, 5-micron slides in a tissue transport kit (recommended but not required) (ARUP supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 4 slides) Protect paraffin block and/or slides from excessive heat.

Storage/Transport Temperature

Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.

Unacceptable Conditions

Specimens fixed or processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives (B-4 or B-5). Frozen specimens. Decalcified specimens.

Remarks

Include surgical pathology report.

Stability

Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable

Reference Interval
Interpretive Data

Refer to report.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
Hotline History
N/A
CPT Codes

88365

Components
Component Test Code* Component Chart Name LOINC
2002148 Block ID 57723-9
2002895 HPV Low Risk ISH Comment 48767-8
2002999 ISH Tissue Source 31208-2
2003001 H and E Slide Description 19772-3
2003008 HPV ISH Low Risk
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • HPV
  • HPV Low Risk ISH
  • HPV LR ISH
  • HPVLOW ISH
  • Human Papillomavirus
  • low-risk HPV ISH
  • LR-HPV ISH
Human Papillomavirus (HPV) Low Risk by in situ Hybridization, Paraffin