Human Papillomavirus (HPV) Low Risk by in situ Hybridization, Paraffin

3002009
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Example Reports
Negative
Positive

Ordering Recommendation

Use to detect low-risk HPV subtypes. Preferred test to determine potential cancer risk is Human Papillomavirus (HPV) High Risk by in situ Hybridization, Paraffin (3002008).

Mnemonic

HPVLR ISH

Methodology

In situ Hybridization

Performed

Mon-Thu

Reported

2-5 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Tissue.

Specimen Preparation

Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Transport tissue block or 5 unstained positively charged, 5-micron slides in a tissue transport kit (recommended but not required) (ARUP supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 4 slides) Protect paraffin block and/or slides from excessive heat.

Storage/Transport Temperature

Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.

Unacceptable Conditions

Specimens fixed or processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives (B-4 or B-5). Frozen specimens. Decalcified specimens.

Remarks

Include surgical pathology report.
If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of the following: an order comment indicating that the ARUP pathologist should choose the specimen most appropriate for testing (e.g., "Choose best block"), or individual orders for each sample submitted. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added to orders that utilize the first option. If multiple specimens are sent to ARUP without a request for pathologist block/slide selection or individual orders, they will be held until clarification is provided.

Stability

Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable

Reference Interval

Interpretive Data

Refer to report.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
05/18/2020
X
11/18/2019
X
N/A

CPT Codes

88365

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Components

Component Test Code* Component Chart Name LOINC
2002148 Block ID 57723-9
2002895 HPV Low Risk ISH Comment 48767-8
2002999 ISH Tissue Source 31208-2
2003001 H and E Slide Description 19772-3
2003008 HPV ISH Low Risk
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • HPV
  • HPV Low Risk ISH
  • HPV LR ISH
  • HPVLOW ISH
  • Human Papillomavirus
  • low-risk HPV ISH
  • LR-HPV ISH
Human Papillomavirus (HPV) Low Risk by in situ Hybridization, Paraffin