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Human Papillomavirus (HPV) Low Risk by in situ Hybridization, Paraffin
Ordering Recommendation
Use to detect low-risk HPV subtypes. Preferred test to determine potential cancer risk is Human Papillomavirus (HPV) High Risk by in situ Hybridization, Paraffin (3002008).
New York DOH Approval Status
Specimen Required
Tissue.
Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Transport tissue block or 5 unstained positively charged, 5-micron slides in a tissue transport kit (recommended but not required) (ARUP supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 4 slides) Protect paraffin block and/or slides from excessive heat.
Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.
Paraffin block with no tumor tissue remaining. Specimens fixed in any fixative other than 10 percent neutral buffered formalin. Decalcified specimens.
Include surgical pathology report.
If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of the following: an order comment indicating that the ARUP pathologist should choose the specimen most appropriate for testing (e.g., "Choose best block"), or individual orders for each sample submitted. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added to orders that utilize the first option. If multiple specimens are sent to ARUP without a request for pathologist block/slide selection or individual orders, they will be held until clarification is provided.
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
Methodology
In situ Hybridization (ISH)
Performed
Mon-Thu
Reported
2-5 days
Reference Interval
Interpretive Data
Refer to report.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
Hotline History
CPT Codes
88365
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 2002148 | Block ID | 57723-9 |
| 2002895 | HPV Low Risk ISH Comment | 48767-8 |
| 2002999 | ISH Tissue Source | 31208-2 |
| 2003001 | H and E Slide Description | 19772-3 |
| 2003008 | HPV ISH Low Risk |
Aliases
- LR-HPV ISH
- HPV Low Risk ISH
- low-risk HPV ISH
- Human Papillomavirus
- HPV
- HPV LR ISH
- HPVLOW ISH
