Human Papillomavirus (HPV) High Risk by in situ Hybridization, Paraffin

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Ordering Recommendation

Preferred in situ hybridization test to detect high-risk HPV subtypes to determine potential cancer risk.

Mnemonic
HPVHR ISH
Methodology

In situ Hybridization

Performed

Mon-Fri

Reported

2-5 days
Must be in the lab by noon to make that days run.

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Tissue.

Specimen Preparation

Formalin fix (10 percent neutral buffered formalin) and paraffin-embed tissue. Transport tissue block or 5 unstained 5-micron slides in a tissue transport kit (recommended but not required) (ARUP supply #47808). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 4 slides) Protect paraffin block and/or slides from excessive heat.

Storage/Transport Temperature

Room temperature or refrigerated. Ship in cooled container during summer months.

Unacceptable Conditions

Specimens fixed or processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives (B-4 or B-5). Frozen specimens. Decalcified specimens.

Remarks

Include surgical pathology report.

Stability

Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable

Reference Interval
Interpretive Data

Refer to report.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
05/18/2020
X
11/18/2019
X
N/A
CPT Codes

88365

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Components
Component Test Code* Component Chart Name LOINC
2002148 Block ID 57723-9
2002898 HPV High Risk ISH Comment 48767-8
2002999 ISH Tissue Source 31208-2
2003001 H and E Slide Description 19772-3
2003006 HPV ISH High Risk
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • high-risk HPV ISH
  • HPV
  • HPV High Risk ISH
  • HPV HR ISH
  • HPVHI ISH
  • HR-HPV ISH
Human Papillomavirus (HPV) High Risk by in situ Hybridization, Paraffin