3002008
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Human Papillomavirus (HPV) High Risk by in situ Hybridization, Paraffin

HPVHR ISH
Example Reports
Negative
Positive

Ordering Recommendation

Preferred in situ hybridization test to detect high-risk HPV subtypes to determine potential cancer risk.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Tissue.

Specimen Preparation

Formalin fix (10 percent neutral buffered formalin) and paraffin-embed tissue. Transport tissue block or 5 unstained 5-micron slides in a tissue transport kit (recommended but not required) (ARUP supply #47808). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 4 slides) Protect paraffin block and/or slides from excessive heat.

Storage/Transport Temperature

Room temperature or refrigerated. Ship in cooled container during summer months.

Unacceptable Conditions

Paraffin block with no tumor tissue remaining. Specimens fixed in any fixative other than 10 percent neutral buffered formalin. Decalcified specimens.

Remarks

Include surgical pathology report.
If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of the following: an order comment indicating that the ARUP pathologist should choose the specimen most appropriate for testing (e.g., "Choose best block"), or individual orders for each sample submitted. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added to orders that utilize the first option. If multiple specimens are sent to ARUP without a request for pathologist block/slide selection or individual orders, they will be held until clarification is provided.

Stability

Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable

Methodology

In situ Hybridization (ISH)

Performed

Mon-Fri

Reported

2-5 days
Must be in the lab by noon to make that days run.

Reference Interval

Interpretive Data

Refer to report.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

N/A

CPT Codes

88365

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Components

Component Test Code* Component Chart Name LOINC
2002148 Block ID 57723-9
2002898 HPV High Risk ISH Comment 48767-8
2002999 ISH Tissue Source 31208-2
2003001 H and E Slide Description 19772-3
2003006 HPV ISH High Risk
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • high-risk HPV ISH
  • HPV
  • HPV High Risk ISH
  • HPV HR ISH
  • HPVHI ISH
  • HR-HPV ISH
Human Papillomavirus (HPV) High Risk by in situ Hybridization, Paraffin