Ordering Recommendation

Aids in the diagnosis of coccidioidomycosis. Includes screening by immunoassay (IgM and IgG) and confirmation by complement fixation and immunodiffusion. For comprehensive nonreflex testing, refer to Coccidioides Antibodies Panel, Serum (0050588).

Mnemonic

COCCI R

Methodology

Complement Fixation/Immunodiffusion/Enzyme-Linked Immunosorbent Assay (ELISA)

Performed

Sun-Sat

Reported

1-6 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum Separator Tube (SST).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.6 mL). Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens.

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Other body fluids. Contaminated, hemolyzed, icteric, or lipemic specimens.

Remarks

Mark specimens plainly as "acute" or "convalescent".

Stability

Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

Effective May 16, 2022

Test Number
Components
Reference Interval
0050179 Coccidioides Antibodies, IgG by Immunoassay, Serum
0.9 IV or less Negative - No significant level of Coccidioides IgG antibody detected.
1.0-1.4 IV Equivocal - Questionable presence of Coccidioides IgG antibody detected.  Repeat testing in 10-14 days may be helpful.
1.5 IV or greater Positive - Presence of IgG antibody to Coccidioides detected, suggestive of current or past infection.

0050178 Coccidioides Antibodies, IgM by Immunoassay, Serum
0.9 IV or less Negative - No significant level of Coccidioides IgM antibody detected.
1.0-1.4 IV Equivocal - Questionable presence of Coccidioides IgM antibody detected.  Repeat testing in 10-14 days may be helpful.
1.5 IV or greater Positive - Presence of IgM antibody to Coccidioides detected, suggestive of current or recent infection.

  Coccidioide Titer, Complement Fixation Less than 1:2
  Coccidioides by Immunodiffusion, Serum Not detected.

Interpretive Data

Refer to report.

Compliance Category

FDA

Note

Coccidioides Antibodies, IgM and IgG by Immunoassay, Serum is used to screen for coccidioidal antibodies. If the immunoassay testing is equivocal or positive for IgM and/or IgG, then Coccidioides Antibodies by Immunodiffusion and Coccidioides Antibody Titer by Complement Fixation, Serum will be added. Additional charges apply.

Hotline History

N/A

CPT Codes

86635 x2; if reflexed add 86635 x2

Components

Component Test Code* Component Chart Name LOINC
0050178 Coccidioides Antibody, IgM by ELISA 90448-2
0050179 Coccidioides Antibody, IgG by ELISA 27009-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • CF
  • Coccidioides immitis
  • Coccidioidomycosis
  • Precipitin
  • TP
  • Valley fever
Coccidioides Antibodies Reflexive Panel, Serum