Ordering Recommendation

Preferred serology test to detect coccidioidomycosis (Valley fever).

Mnemonic
COCCI R
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay, Semi-Quantitative Complement Fixation, Qualitative Immunodiffusion

Performed

Sun-Sat

Reported

1-3 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum Separator Tube (SST).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens.

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Contaminated, hemolyzed, or severely lipemic specimens.

Remarks

Please mark specimens plainly as "acute" or "convalescent."

Stability

Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval
Test Number
Components
Reference Interval
0050179 Coccidioides Antibody, IgG by ELISA
0.9 IV or less Negative - No significant level of Coccidioides IgG antibody detected.
1.0-1.4 IV Equivocal - Questionable presence of Coccidioides IgG antibody detected.  Repeat testing in 10-14 days may be helpful.
1.5 IV or greater Positive - Presence of IgG antibody to Coccidioides detected, suggestive of current or past infection.

0050178 Coccidioides Antibody, IgM by ELISA
0.9 IV or less Negative - No significant level of Coccidioides IgM antibody detected.
1.0-1.4 IV Equivocal - Questionable presence of Coccidioides IgM antibody detected.  Repeat testing in 10-14 days may be helpful.
1.5 IV or greater Positive - Presence of IgM antibody to Coccidioides detected, suggestive of current or recent infection.

0050183 Coccidioides immitis Antibodies by Immunodiffusion None detected.
  Coccidioide Titer, Complement Fixation Less than 1:2

Interpretive Data

Refer to report.

No compliance statements are in use for this test.

Note

Negative fungal serology does not rule out the possibility of current infection. Coccidioides Antibody IgG and IgM by ELISA are used to screen for Coccidioides antibodies. If the ELISA testing is equivocal or positive for IgG and/or IgM, then Coccidioides immitis Angibodies by Immunodiffusion, and Coccidioide Titer will be added. Additional charges apply.

Hotline History
N/A
CPT Codes

86635 x2; if reflexed add 86635 x2

Components
Component Test Code* Component Chart Name LOINC
0050178 Coccidioides Antibody, IgM by ELISA 90448-2
0050179 Coccidioides Antibody, IgG by ELISA 27009-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
Coccidioides Antibody Reflexive Panel