May be useful for evaluation of patients with characteristic cutaneous manifestations of dermatomyositis with or without muscle weakness.
Qualitative Immunoprecipitation/Qualitative Immunoblot
Serum Separator Tube (SST).
Separate from cells ASAP or within 2 hours of collection. Transfer one 1 mL serum aliquots to ARUP Standard Transport Tubes. (Min: 0.5 mL/aliquot)
Hemolyzed, hyperlipemic, icteric, heat-treated or contaminated specimens.
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year
|Mi-2 (nuclear helicase protein) Antibody||Negative|
|SAE1 (SUMO activating enzyme) Ab||Negative|
|MDA5 (CADM-140) Ab||Negative|
|NXP2 (Nuclear matrix protein-2) Ab||Negative|
|TIF-1 gamma (155 kDa) Ab||Negative|
Refer to report.
Compliance Statement D: For laboratory tests using a manufactured RUO kit. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
Antibodies: Mi-2, P155/140, SAE1, MDA5, NXP2, TIF1-gamma
|Component Test Code*||Component Chart Name||LOINC|
|2010852||Mi-2 (nuclear helicase protein) Antibody||18485-3|
|2013996||Dermatomyositis Interpretive Information||48767-8|
|3001786||SAE1 (SUMO activating enzyme) Ab||82440-9|
|3001787||MDA5 (CADM-140) Ab||82424-3|
|3001788||NXP2 (Nuclear matrix protein-2) Ab||82426-8|
|3001789||TIF-1 gamma (155 kDa) Ab||82448-2|