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Dermatomyositis Autoantibody Panel
Ordering Recommendation
May be useful for evaluation of patients with characteristic cutaneous manifestations of dermatomyositis with or without muscle weakness.
New York DOH Approval Status
Specimen Required
Serum separator tube (SST)
Separate from cells ASAP or within 2 hours of collection. Transfer 3 to 4 mL to ARUP standard transport tube. (Min: 1.5 mL)
Refrigerated
Hemolyzed, hyperlipemic, icteric, heat-treated, or contaminated specimens
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year
Methodology
Qualitative Immunoprecipitation / Qualitative Immunoblot / Semi-Quantitative Indirect Fluorescent Antibody (IFA) / Qualitative Particle-Based Multianalyte Technology (PMAT)
Performed
Sun-Sat
Reported
7-18 days
Reference Interval
| Test Number |
Components |
Reference Interval |
|---|---|---|
| TIF-1 gamma (155 kDa) Ab | Negative | |
| NXP2 (Nuclear matrix protein-2) Ab | Negative | |
| MDA5 (CADM-140) Ab | Negative | |
| SAE1 (SUMO activating enzyme) Ab | Negative | |
| Antinuclear Antibody (ANA), HEp-2, IgG | Less than 1:80 | |
| P155/140 Antibody | Negative | |
| Mi-2 (nuclear helicase protein) Antibody | Negative |
Interpretive Data
Refer to report.
Laboratory Developed Test (LDT)
Note
Antibodies: Mi-2, P155/140, SAE1, MDA5, NXP2, TIF1-gamma, ANA
Hotline History
Hotline History
CPT Codes
83516 x6; 86039
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 2010852 | Mi-2 (nuclear helicase protein) Antibody | 18485-3 |
| 2010855 | P155/140 Antibody | 8061-4 |
| 2013996 | Dermatomyositis Interpretive Information | 48767-8 |
| 3000090 | Antinuclear Antibody (ANA), HEp-2, IgG | 21424-7 |
| 3000096 | ANA Interpretive Comment | 49311-4 |
| 3001786 | SAE1 (SUMO activating enzyme) Ab | |
| 3001787 | MDA5 (CADM-140) Ab | |
| 3001788 | NXP2 (Nuclear matrix protein-2) Ab | |
| 3001789 | TIF-1 gamma (155 kDa) Ab |
