Ordering Recommendation

Assist in distinguishing between inherited and acquired forms of thrombotic thrombocytopenic purpura (TTP).  Not recommended as initial test for identification of autoantibodies to ADAMTS13, since the ADAMTS13 antibody test is less specific for acquired TTP than ADAMTS13 Inhibitor (3000228).  Order when acquired TTP is suspected but antibodies are not identified by the ADAMTS13 inhibitor test.  

Mnemonic
ADAMTS AB
Methodology

Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Tue

Reported

1-8 days

New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation

Draw specimen prior to plasma exchange therapy.

Collect

Light Blue (Sodium Citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.

Specimen Preparation

Transfer 1 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Serum or EDTA plasma. Clotted or hemolyzed specimens.

Remarks
Stability

Ambient: 2 hours; Refrigerated: Unacceptable; Frozen: 2 weeks (No freeze/thaw cycles.)

Reference Interval

Negative: Less than 12 U/mL
Borderline: 12-15 U/mL
Positive: Greater than 15 U/mL

Interpretive Data



Compliance Category

Laboratory Developed Test (LDT)

Note
Hotline History
N/A
CPT Codes

83520

Components
Component Test Code* Component Chart Name LOINC
3000192 ADAMTS13 Antibody 34590-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • VWF Cleaving Protease Antibody
ADAMTS13 Antibody