Assist in distinguishing between inherited and acquired forms of thrombotic thrombocytopenic purpura (TTP). Not recommended as initial test for identification of autoantibodies to ADAMTS13, since the ADAMTS13 antibody test is less specific for acquired TTP than ADAMTS13 Inhibitor (3000228). Order when acquired TTP is suspected but antibodies are not identified by the ADAMTS13 inhibitor test.
Quantitative Enzyme-Linked Immunosorbent Assay
Draw specimen prior to plasma exchange therapy.
Light Blue (Sodium Citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.
Transfer 1 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Serum or EDTA plasma. Clotted or hemolyzed specimens.
Ambient: 2 hours; Refrigerated: Unacceptable; Frozen: 2 weeks (No freeze/thaw cycles.)
Negative: Less than 12 U/mL
Borderline: 12-15 U/mL
Positive: Greater than 15 U/mL
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
|Component Test Code*||Component Chart Name||LOINC|
- VWF Cleaving Protease Antibody