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Coccidioides Antibodies by Complement Fixation, CSF
Ordering Recommendation
Aids in the diagnosis of coccidioidal meningitis and in monitoring of coccidioidal antibody titer in CSF in response to treatment. For comprehensive diagnostic testing that includes immunoassay (IgM and IgG), complement fixation, and immunodiffusion, refer to Coccidioides Antibodies Panel, CSF (3000061).
New York DOH Approval Status
Specimen Required
CSF
Transfer 1 mL CSF to an ARUP standard transport tube. (Min 0.6 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of acute specimens.
Refrigerated.
Other body fluids. Contaminated, hemolyzed, xanthochromic, or severely lipemic specimens.
Mark specimens plainly as "acute" or "convalescent."
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Methodology
Semi-Quantitative Complement Fixation
Performed
Sun-Sat
Reported
2-4 days
Reference Interval
Less than 1:2
Interpretive Data
A titer of 1:2 or greater suggests past or current infection. However, greater than 30 percent of cases with chronic residual pulmonary disease have negative complement fixation (CF) tests. Titers of less than 1:32 (even as low as 1:2) may indicate past infection or self-limited disease; anticoccidioidal CF antibody titers in excess of 1:16 may indicate disseminated infection. CF serology may be used to follow therapy. Antibody in CSF is considered diagnostic for coccidioidal meningitis, although 10 percent of patients with coccidioidal meningitis will not have antibody in CSF.
Modified FDA
Note
Hotline History
CPT Codes
86635
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0050711 | Coccidioides Ab by CF, CSF | 13917-0 |
Aliases
- CF
- Coccidioides immitis
- Coccidioidomycosis
- Precipitin
- Valley Fever
- TP
