Ordering Recommendation

Use to screen for the presence of coccidioidal IgM and IgG antibodies in CSF. Not recommended as a standalone test. For comprehensive diagnostic testing that includes immunoassay (IgM and IgG), complement fixation, and immunodiffusion, refer to Coccidioides Antibodies Panel, CSF (3000061).

Mnemonic

COCCIGMCSF

Methodology

Enzyme-Linked Immunosorbent Assay (ELISA)

Performed

Sun-Sat

Reported

1-3 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

CSF.

Specimen Preparation

Transfer 2 mL CSF to an ARUP Standard Transport Tube. (Min: 0.3 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens.

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Other body fluids. Contaminated, hemolyzed, xanthochromic, or severely lipemic specimens.

Remarks

Mark specimens plainly as "acute" or "convalescent".

Stability

Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

Test Number
Components
Reference Interval
  Coccidioides Antibody IgG ELISA, CSF 0.2 IV or less
  Coccidioides Antibody IgM ELISA, CSF 0.2 IV or less

Interpretive Data




Component Interpretation
Coccidioides Antibodies IgG by Immunoassay, CSF 0.2 IV or less  Negative - No significant level of Coccidioides IgG antibody detected.
0.3 IV or greater  Positive - Presence of IgG antibody to Coccidioides detected, suggestive of current or past infection.
Coccidioides Antibodies IgM by Immunoassay, CSF 0.2 IV or less  Negative - No significant level of Coccidioides IgM antibody detected.
0.3 IV or greater  Positive - Presence of IgM antibody to Coccidioides detected, suggestive of current or recent infection.

Compliance Category

Modified FDA

Note

This immunoassay uses recombinant and native Coccidioides antigens, including CF and TP antigens.

Hotline History

N/A

CPT Codes

86635 x2

Components

Component Test Code* Component Chart Name LOINC
3000062 Coccidioides Antibody IgG ELISA, CSF 16638-9
3000063 Coccidioides Antibody IgM ELISA, CSF 16639-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • CF
  • Coccidioides immitis
  • Coccidioidomycosis
  • Precipitin
  • TP
  • Valley fever
Coccidioides Antibodies, IgM and IgG by Immunoassay, CSF