Ordering Recommendation

Aid in diagnosis of coccidioidal meningitis (Valley fever). Preferred test is Coccidioides Antibodies Panel, CSF by CF, ID, ELISA (3000061) which combines complement fixation, immunodiffusion, and enzyme-linked immunosorbent assays.

Mnemonic
COCCIGMCSF
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Sun-Sat

Reported

1-3 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

CSF.

Specimen Preparation

Transfer 2 mL CSF to an ARUP Standard Transport Tube. (Min: 0.3 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens.

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Contaminated, hemolyzed, xanthochromic, or severely lipemic specimens.

Remarks

Please Mark specimens plainly as "acute" or "convalescent."

Stability

Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval
Test Number
Components
Reference Interval
3000055 Coccidioides Antibody IgG ELISA, CSF
0.2 IV or less Negative - No significant level of Coccidioides IgG antibody detected.
0.3 IV or greater Positive - Presence of IgG antibody to Coccidioides detected, suggestive of current or past infection.

3000056 Coccidioides Antibody IgM ELISA, CSF
0.2 IV or less Negative - No significant level of Coccidioides IgM antibody detected.
0.3 IV or greater Positive - Presence of IgM antibody to Coccidioides detected, suggestive of current or recent infection.

Interpretive Data

Refer to report.

Compliance Category

Modified FDA

Note

Negative fungal serology does not rule out the possibility of current infection.

Hotline History
N/A
CPT Codes

86635 x2

Components
Component Test Code* Component Chart Name LOINC
3000062 Coccidioides Antibody IgG ELISA, CSF 16638-9
3000063 Coccidioides Antibody IgM ELISA, CSF 16639-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Cocci Abs ELISA
  • Cocci IgG, IgM Abs
Coccidioides Antibodies, IgG and IgM by ELISA, CSF