Ordering Recommendation

Use to screen for the presence of coccidioidal IgM antibodies in CSF. Not recommended as a standalone test. For comprehensive diagnostic testing that includes immunoassay (IgM and IgG), complement fixation, and immunodiffusion, refer to Coccidioides Antibodies Panel, CSF (3000061).

Mnemonic

COCCIM CSF

Methodology

Enzyme-Linked Immunosorbent Assay (ELISA)

Performed

Sun-Sat

Reported

1-3 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

CSF.

Specimen Preparation

Transfer 1 mL CSF to an ARUP Standard Transport Tube. (Min: 0.3 mL). Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens.

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Other body fluids. Contaminated, hemolyzed, xanthochromic, or severely lipemic specimens.

Remarks

Mark specimens plainly as "acute" or "convalescent".

Stability

Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

0.2 IV or less Negative - No significant level of Coccidioides IgM antibody detected.
0.3 IV or greater Positive - Presence of IgM antibody to Coccidioides detected, suggestive of current or recent infection.

Interpretive Data

In most symptomatic patients, IgM antibodies usually appear by the second week of infection and disappear by the fourth month. Both tube precipitin (TP) and CF antigens are represented in the ELISA tests.

Compliance Category

Modified FDA

Note

This immunoassay uses recombinant and native Coccidioides antigens, including CF and TP antigens.

Hotline History

N/A

CPT Codes

86635

Components

Component Test Code* Component Chart Name LOINC
3000063 Coccidioides Antibody IgM ELISA, CSF 16639-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • CF
  • Coccidioides immitis
  • Coccidioidomycosis
  • Precipitin
  • TP
  • Valley fever
Coccidioides Antibodies IgM by Immunoassay, CSF