Coccidioides Antibody IgM ELISA, CSF

3000056
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Example Reports
Negative
Positive
Ordering Recommendation

Not recommended as a stand-alone test. For diagnosis of coccidioidal meningitis (Valley fever), refer to Coccidioides Antibodies Panel, CSF by CF, ID, ELISA (3000061) which combines complement fixation, immunodiffusion, and enzyme-linked immunosorbent assays.

Mnemonic
COCCIM CSF
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Sun-Sat

Reported

1-3 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

CSF.

Specimen Preparation

Transfer 1 mL CSF to an ARUP Standard Transport Tube. (Min: 0.3 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens.

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Contaminated, hemolyzed, xanthochromic, or severely lipemic specimens.

Remarks

Mark specimens plainly as "acute" or "convalescent".

Stability

Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval
0.2 IV or less Negative - No significant level of Coccidioides IgM antibody detected.
0.3 IV or greater Positive - Presence of IgM antibody to Coccidioides detected, suggestive of current or recent infection.

Interpretive Data

In most symptomatic patients, IgM antibodies usually appear by the second week of infection and disappear by the fourth month. Both tube precipitin (TP) and CF antigens are represented in the ELISA tests. 

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Modified FDA

Note

Negative fungal serology does not rule out the possibility of current infection.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
08/03/2020
X
05/18/2020
X
N/A
CPT Codes

86635

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Components
Component Test Code* Component Chart Name LOINC
3000063 Coccidioides Antibody IgM ELISA, CSF 16639-7
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Aliases
  • Cocci IgM
  • Coccidioides IgM antibody
  • San Joaquin Fever antibodies
  • Valley fever antibodies
Coccidioides Antibody IgM ELISA, CSF