Ordering Recommendation

Not recommended as a stand-alone test. For diagnosis of coccidioidal meningitis (Valley fever), refer to Coccidioides Antibodies Panel, CSF by CF, ID, ELISA (3000061) which combines complement fixation, immunodiffusion, and enzyme-linked immunosorbent assays.


Semi-Quantitative Enzyme-Linked Immunosorbent Assay




1-3 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation


Specimen Preparation

Transfer 1 mL CSF to an ARUP Standard Transport Tube. (Min: 0.3 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens.

Storage/Transport Temperature


Unacceptable Conditions

Contaminated, hemolyzed, xanthochromic, or severely lipemic specimens.


Mark specimens plainly as "acute" or "convalescent".


Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval
0.9 IV or less Negative - No significant level of Coccidioides IgM antibody detected.
1.0-1.4 IV Equivocal - Questionable presence of Coccidioides IgM antibody detected. Repeat testing in 10-14 days may be helpful.
1.5 IV or greater Positive - Presence of IgM antibody to Coccidioides detected, suggestive of current or recent infection.

Interpretive Data

In most symptomatic patients, IgM antibodies usually appear by the second week of infection and disappear by the fourth month. Both tube precipitin (TP) and CF antigens are represented in the ELISA tests.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.


Negative fungal serology does not rule out the possibility of current infection.

Hotline History
CPT Codes


Component Test Code* Component Chart Name LOINC
3000063 Coccidioides Antibody IgM ELISA, CSF 16639-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Cocci IgM
  • Coccidioides IgM antibody
  • San Joaquin Fever antibodies
  • Valley fever antibodies
Coccidioides Antibody IgM ELISA, CSF