Not recommended as a stand-alone test. For diagnosis of coccidioidal meningitis (Valley fever), refer to Coccidioides Antibodies Panel, CSF by CF, ID, ELISA (3000061) which combines complement fixation, immunodiffusion, and enzyme-linked immunosorbent assays.
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Transfer 1 mL CSF to an ARUP Standard Transport Tube. (Min: 0.3 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens.
Contaminated, hemolyzed, xanthochromic, or severely lipemic specimens.
Mark specimens plainly as "acute" or "convalescent".
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
|0.2 IV or less||Negative - No significant level of Coccidioides IgM antibody detected.|
|0.3 IV or greater||Positive - Presence of IgM antibody to Coccidioides detected, suggestive of current or recent infection.|
In most symptomatic patients, IgM antibodies usually appear by the second week of infection and disappear by the fourth month. Both tube precipitin (TP) and CF antigens are represented in the ELISA tests.
Negative fungal serology does not rule out the possibility of current infection.
|Component Test Code*||Component Chart Name||LOINC|
|3000063||Coccidioides Antibody IgM ELISA, CSF||16639-7|
- Cocci IgM
- Coccidioides IgM antibody
- San Joaquin Fever antibodies
- Valley fever antibodies