Not recommended as a stand-alone test. For diagnosis of coccidioidal meningitis (Valley fever), refer to Coccidioides Antibodies Panel, CSF by CF, ID, ELISA (3000061) which combines complement fixation, immunodiffusion, and enzyme-linked immunosorbent assays.
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Transfer 1 mL CSF to an ARUP Standard Transport Tube. (Min: 0.3 mL)
Contaminated, hemolyzed, xanthochromic, or severely lipemic specimens.
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
|0.2 IV or less||Negative - No significant level of Coccidioides IgG antibody detected.|
|0.3 IV or greater||Positive - Presence of IgG antibody to Coccidioides detected, suggestive of current or past infection.|
IgG antibodies usually appear by the third week of infection and may persist for years. Both tube precipitin (TP) and CF antigens are represented in the ELISA tests.
Negative fungal serology does not rule out the possibility of current infection.
|Component Test Code*||Component Chart Name||LOINC|
|3000062||Coccidioides Antibody IgG ELISA, CSF||16638-9|
- Cocci IgG
- Coccidioides IgG antibody
- San Joaquin Fever antibodies
- Valley fever antibodies