Ordering Recommendation

Not recommended as a stand-alone test. For diagnosis of coccidioidal meningitis (Valley fever), refer to Coccidioides Antibodies Panel, CSF by CF, ID, ELISA (3000061) which combines complement fixation, immunodiffusion, and enzyme-linked immunosorbent assays.

Mnemonic
COCCIG CSF
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Sun-Sat

Reported

1-3 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

CSF

Specimen Preparation

Transfer 1 mL CSF to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Contaminated, hemolyzed, xanthochromic, or severely lipemic specimens.

Remarks
Stability

Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval
0.2 IV or less Negative - No significant level of Coccidioides IgG antibody detected.
0.3 IV or greater Positive - Presence of IgG antibody to Coccidioides detected, suggestive of current or past infection.

Interpretive Data

IgG antibodies usually appear by the third week of infection and may persist for years. Both tube precipitin (TP) and CF antigens are represented in the ELISA tests.

Compliance Category

Modified FDA

Note

Negative fungal serology does not rule out the possibility of current infection.

Hotline History
N/A
CPT Codes

86635

Components
Component Test Code* Component Chart Name LOINC
3000062 Coccidioides Antibody IgG ELISA, CSF 16638-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Cocci IgG
  • Coccidioides IgG antibody
  • San Joaquin Fever antibodies
  • Valley fever antibodies
Coccidioides Antibody IgG ELISA, CSF