Aquaporin-4 Antibody, IgG by CBA-IFA with Reflex to Titer, Serum

2013320
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Additional Technical Information

Ordering Recommendation

Useful in the initial evaluation of neuromyelitis optica (NMO) spectrum disorders. This test uses a cell-based assay (CBA) to detect antibodies against aquaporin-4.

Mnemonic

AQP4 SER

Methodology

Semi-Quantitative Cell-Based Indirect Fluorescent Antibody

Performed

Mon, Wed, Fri

Reported

1-6 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

N/A

Collect

Serum Separator Tube (SST) or Plain Red.

Specimen Preparation

Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Contaminated.

Remarks

N/A

Stability

Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval

Less than 1:10

Interpretive Data

Diagnosis of neuromyelitis optica (NMO) requires the presence of longitudinally extensive acute myelitis (lesions extending over 3 or more vertebral segments) and optic neuritis. Approximately 75 percent of patients with NMO express antibodies to the aquaporin-4 (AQP4) receptor. While the absence of AQP4 receptor antibodies does not rule out a diagnosis of NMO, presence of this antibody is diagnostic for NMO.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

If AQP4 antibody IgG is positive, then an AQP4 antibody IgG titer is reported. Additional charges apply.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
08/15/2022
X
X
N/A

CPT Codes

86052; if reflexed, add 86256

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Components

Component Test Code* Component Chart Name LOINC
2013322 Neuromyelitis Optica/AQP4-IgG, Serum 63439-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • AQP
  • AQP4
  • AQP4 antibody
  • Aquaporin
  • Cell-based assay
  • Cell-binding assay
  • CNS demyelinating disease
  • Devic's Ab
  • Devic's Antibody
  • Myelopathy
  • Neuromyelitis Optica (NMO) Antibody
  • Neuromyelitis Optica IgG
  • NMO-IgG
  • NMOSD
  • Optic Neuritis Ab
  • Optic Neuritis Antibody
  • Optic-Spinal MS Antibody
  • Pediatric CNS disorders
  • Soft-NMOS
  • Transverse Myelitis Ab
  • Vision Loss Ab
Aquaporin-4 Antibody, IgG by CBA-IFA with Reflex to Titer, Serum