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Aquaporin-4 Receptor Antibody, IgG by IFA with Reflex to Titer, Serum
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Ordering Recommendation
Useful in the initial evaluation of neuromyelitis optica (NMO) spectrum disorders. This test uses a cell-based assay (CBA) to detect antibodies against aquaporin-4.
Mnemonic
Methodology
Semi-Quantitative Indirect Fluorescent Antibody
Performed
Mon, Wed, Fri
Reported
1-6 days
New York DOH Approval Status
Specimen Required
N/A
Serum Separator Tube (SST) or Plain Red.
Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL)
Refrigerated.
Contaminated.
N/A
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year
Reference Interval
Less than 1:10
Interpretive Data
Diagnosis of neuromyelitis optica (NMO) requires the presence of longitudinally extensive acute myelitis (lesions extending over 3 or more vertebral segments) and optic neuritis. Approximately 75 percent of patients with NMO express antibodies to the aquaporin-4 (AQP4) receptor. While the absence of AQP4 receptor antibodies does not rule out a diagnosis of NMO, presence of this antibody is diagnostic for NMO.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
If AQP4 antibody IgG is positive, then an AQP4 antibody IgG titer is reported. Additional charges apply.
Hotline History
CPT Codes
86052; if reflexed, add 86256
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 2013322 | Neuromyelitis Optica/AQP4-IgG, Serum | 63439-4 |
Aliases
- AQP
- AQP4
- AQP4 antibody
- Aquaporin
- Devic's Ab
- Devic's Antibody
- Neuromyelitis Optica (NMO) Antibody
- Neuromyelitis Optica IgG
- NMO-IgG
- Optic Neuritix Ab
- Optic Neuritix Antibody
- Optic-Spinal MS Antibody
- Soft-NMOS
- Transverse Myelitis Ab
- Vision Loss Ab
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