Ordering RecommendationRecommendations when to order or not order the test. May include related or preferred tests.
Useful for initial evaluation of NMO spectrum disorders.
MnemonicUnique test identifier.
AQP4 SER
MethodologyProcess(es) used to perform the test.
Semi-Quantitative Indirect Fluorescent Antibody
PerformedDays of the week the test is performed.
Mon, Wed, Fri
ReportedExpected turnaround time for a result, beginning when ARUP has received the specimen.
1-6 days
New York DOH Approval StatusIndicates test has been approved by the New York State Department of Health.
This test is New York DOH approved.
Specimen Required
Patient Preparation
N/A
Collect
Serum Separator Tube (SST) or Plain Red.
Specimen Preparation
Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL)
Storage/Transport Temperature
Refrigerated.
Unacceptable Conditions
Contaminated.
Remarks
N/A
Stability
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year
Reference IntervalNormal range/expected value(s) for a specific disease state. May also include abnormal ranges.
Less than 1:10
Interpretive DataBackground information for test. May include disease information, patient result explanation, recommendations, details of testing, associated diseases, explanation of possible patient results.
Diagnosis of neuromyelitis optica (NMO) requires the presence of longitudinally extensive acute myelitis (lesions extending over 3 or more vertebral segments) and optic neuritis. Approximately 75 percent of patients with NMO express antibodies to the aquaporin-4 (AQP4) receptor. While the absence of AQP4 receptor antibodies does not rule out a diagnosis of NMO, presence of this antibody is diagnostic for NMO.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Compliance Category
Laboratory Developed Test (LDT)
NoteAdditional information related to the test.
If AQP4 antibody IgG is positive, then an AQP4 antibody IgG titer is reported. Additional charges apply.
Hotline History
N/A
CPT CodesThe American Medical Association Current Procedural Terminology (CPT) codes published in ARUP's Laboratory Test Directory are provided for informational purposes only. The codes reflect our interpretation of CPT coding requirements based upon AMA guidelines published annually. CPT codes are provided only as guidance to assist clients with billing. ARUP strongly recommends that clients confirm CPT codes with their Medicare administrative contractor, as requirements may differ. CPT coding is the sole responsibility of the billing party. ARUP Laboratories assumes no responsibility for billing errors due to reliance on the CPT codes published.
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
AliasesOther names that describe the test. Synonyms.
AQP
AQP4
AQP4 antibody
Aquaporin
Devic's Ab
Devic's Antibody
Neuromyelitis Optica (NMO) Antibody
Neuromyelitis Optica IgG
NMO-IgG
Optic Neuritix Ab
Optic Neuritix Antibody
Optic-Spinal MS Antibody
Soft-NMOS
Transverse Myelitis Ab
Vision Loss Ab
Aquaporin-4 Receptor Antibody, IgG by IFA with Reflex to Titer, Serum
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