Ordering Recommendation

May be a useful tool for distinguishing ulcerative colitis (UC) from Crohn disease (CD) in patients with suspected inflammatory bowel disease.

Mnemonic
IBD PAN
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Indirect Fluorescent Antibody

Performed

Sat-Sun

Reported

1-4 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

N/A

Collect

Serum Separator Tube (SST).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.6 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Contaminated, heat-inactivated, hemolyzed, or severely lipemic specimens.

Remarks

N/A

Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval
Test Number
Components
Reference Interval
  S. cerevisiae Antibody, IgG
20.0 Units or less Negative
20.1-24.9 Units Equivocal
25.0 Units or greater Positive

  S. cerevisiae Antibody, IgA
20.0 Units or less Negative
20.1-24.9 Units Equivocal
25.0 Units or greater Positive

0050811 Anti-Neutrophil Cytoplasmic Antibody, IgG Less than 1:20: Not significant

Interpretive Data

Refer to report.

Compliance Category

FDA

Note

This test may be a useful tool for distinguishing ulcerative colitis (UC) from Crohn disease (CD) in patients with suspected inflammatory bowel disease. If the ANCA screen detects antibodies at a 1:20 dilution or greater, then a titer to end point will be added. Additional charges apply. ANCA IFA is simultaneously tested on ethanol- and formalin-fixed slides to allow differentiation of C- and P-ANCA patterns.

Hotline History
N/A
CPT Codes

86671 x2; 86255; if reflexed, add 86256

Components
Component Test Code* Component Chart Name LOINC
0050562 S. cerevisiae Antibody, IgG 47321-5
0050563 S. cerevisiae Antibody, IgA 47320-7
0050811 Anti-Neutrophil Cytoplasmic Ab, IgG 29967-7
2013271 EER Inflammatory Bowel Disease Panel 11526-1
2013448 Inflammatory Bowel Disease Interp 62364-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • ASCA
  • atypical p-ANCA Ab
  • atypical p-ANCA IgG
  • Atypical perinuclear anticytoplasmic neutrophil Ab
  • Atypical perinuclear anticytoplasmic neutrophil IgG
  • IBD Differentiation Profile
  • S. cerevisiae Ab
  • Saccharomyces cerevisiae Antibody
Inflammatory Bowel Disease Differentiation Panel