Ordering Recommendation

Recommended panel for the evaluation of patients at risk for inflammatory bowel disease. May also be useful in differentiating patients with ulcerative colitis (UC) from those with Crohn disease (CD).

Mnemonic

IBD-PAN

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Indirect Fluorescent Antibody

Performed

Sat-Sun

Reported

1-4 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

N/A

Collect

Serum Separator Tube (SST).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.6 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Contaminated, heat-inactivated, hemolyzed, or severely lipemic specimens.

Remarks

N/A

Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

Test Number
Components
Reference Interval
  S. cerevisiae Antibody, IgG
20.0 Units or less Negative
20.1-24.9 Units Equivocal
25.0 Units or greater Positive

  S. cerevisiae Antibody, IgA
20.0 Units or less Negative
20.1-24.9 Units Equivocal
25.0 Units or greater Positive

  ANCA IFA Titer Less than 1:20
  ANCA IFA Pattern None Detected

Interpretive Data

Refer to report.

Compliance Category

FDA

Note

This test may be a useful tool for distinguishing ulcerative colitis (UC) from Crohn disease (CD) in patients with suspected inflammatory bowel disease. ANCA IFA is simultaneously tested on ethanol- and formalin-fixed slides to allow differentiation of C- and P-ANCA patterns.

Hotline History

N/A

CPT Codes

86671 x2; 86255

Components

Component Test Code* Component Chart Name LOINC
0050562 S. cerevisiae Antibody, IgG 47321-5
0050563 S. cerevisiae Antibody, IgA 47320-7
2013448 Inflammatory Bowel Disease Interp 62364-5
3003764 ANCA IFA Pattern 21419-7
3003765 ANCA IFA Titer 29967-7
3003768 EER Inflammatory Bowel Diseases 11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • ASCA
  • atypical p-ANCA Ab
  • atypical p-ANCA IgG
  • Atypical perinuclear anticytoplasmic neutrophil Ab
  • Atypical perinuclear anticytoplasmic neutrophil IgG
  • IBD Differentiation Profile
  • S. cerevisiae Ab
  • Saccharomyces cerevisiae Antibody
Inflammatory Bowel Disease Differentiation Panel