Ordering Recommendation

Useful for general screening in contexts of compliance and/or abuse. A screen with reflex testing is the preferred method for ruling out methadone exposure. For follow-up testing of a presumptive result, Methadone and Metabolite, Urine, Quantitative (0090362) is preferred.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Specimen Preparation

Transfer 4 mL urine with no additives or preservatives to an ARUP Standard Transport Tube. (Min:  2 mL)

Storage/Transport Temperature

Room temperature.

Unacceptable Conditions

Breast Milk. Specimens exposed to repeated freeze/thaw cycles.


Ambient: 1 week; Refrigerated: 1 month; Frozen: 1 month


Qualitative Enzyme Immunoassay/Quantitative Liquid Chromatography-Tandem Mass Spectrometry




1-4 days

Reference Interval

Screen cutoff concentration: 150 ng/mL

Interpretive Data

The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, diluted/adulterated urine, or limitations of testing. The concentration at which the screening test can detect a drug or metabolite varies. Specimens for which drugs or drug classes are detected by the screen are reflexed to a second, more specific technology (GC/MS and/or LC-MS/MS). The concentration value must be greater than or equal to the cutoff to be reported as positive. Interpretive questions should be directed to the laboratory.

For medical purposes only; not valid for forensic use.

Compliance Category



If the specimen screens positive, then Confirmation/Quantitation by LC-MS/MS (ARUP test code 0090362) will be added to confirm result. Additional charges apply.

Compare to Pain Management, Methadone, Quantitative, with medMatch, Urine; Pain Management, Methadone, with Confirmation with medMatch, Urine.

Hotline History


CPT Codes

80307; if reflexed, add 80358 (Reflexed Alt Code: G0480 )


Component Test Code* Component Chart Name LOINC
0092199 Methadone, Urn, Screen 19550-3
2012212 Screen, Urine Interpretation 54247-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Amidone
  • Dolophine
  • EDDp
  • Heptadon
  • Methadose
  • Pain Management
  • Physeptone
  • Symoron
Methadone, Urine Screen with Reflex to Quantitation