Optimize drug therapy and monitor patient adherence. Test only measures desipramine concentration. If imipramine will be administered, order Imipramine and Desipramine, Serum or Plasma (0090157).
Quantitative Liquid Chromatography/Tandem Mass Spectrometry
Mon, Wed, Fri
New York DOH Approval Status
Serum Pre-dose (Trough) Draw - At a Steady State Concentration or Plasma Pre-dose (Trough) Draw - At a Steady State Concentration in Plain Red, Lavender (K2EDTA), Lavender (K3EDTA), or Pink (K2EDTA).
Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Whole blood. Gel Separator Tubes, Light Blue (Sodium Citrate), or Yellow (SPS or ACD Solution).
Ambient: 5 days; Refrigerated: 2 weeks; Frozen: 6 months
|Therapeutic Range:||100-300 ng/mL|
|Toxic:||Greater than 500 ng/mL|
The therapeutic range is based on serum pre-dose (trough) draw at steady-state concentration. Toxic concentrations may cause anticholinergic effects, drowsiness and cardiac abnormalities.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
80335 (Alt code: G0480)
|Component Test Code*||Component Chart Name||LOINC|
|2011491||Desipramine Serum or Plasma||3531-1|
- Tricyclic Antidepressants