Ordering Recommendation

Optimize drug therapy and monitor patient adherence. Test only measures desipramine concentration. If imipramine will be administered, order Imipramine and Desipramine, Serum or Plasma (0090157).




Quantitative Liquid Chromatography-Tandem Mass Spectrometry


Mon, Wed, Fri


1-5 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Serum Pre-dose (Trough) Draw - At a Steady State Concentration or Plasma Pre-dose (Trough) Draw - At a Steady State Concentration in Plain Red, Lavender (K2EDTA), Lavender (K3EDTA), or Pink (K2EDTA).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature


Unacceptable Conditions

Whole blood. Gel Separator Tubes, Light Blue (Sodium Citrate), or Yellow (SPS or ACD Solution).


Ambient: 5 days; Refrigerated: 2 weeks; Frozen: 6 months

Reference Interval

Therapeutic Range: 100-300 ng/mL
Toxic: Greater than 500 ng/mL

Interpretive Data

The therapeutic range is based on serum pre-dose (trough) draw at steady-state concentration. Toxic concentrations may cause anticholinergic effects, drowsiness and cardiac abnormalities.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


Hotline History


CPT Codes

80335 (Alt code: G0480)


Component Test Code* Component Chart Name LOINC
2011491 Desipramine Serum or Plasma 3531-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


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Desipramine, Serum or Plasma by Tandem Mass Spectrometry