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Imipramine and Desipramine, Serum or Plasma
Ordering Recommendation
Optimize drug therapy and monitor patient adherence.
Methodology
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed
Mon, Wed, Fri
Reported
1-5 days
New York DOH Approval Status
Specimen Required
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.
Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2 EDTA).
Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Refrigerated.
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).
After separation from cells: Ambient: 5 days; Refrigerated: 2 weeks; Frozen: 6 months
Reference Interval
Effective February 19, 2013
| Therapeutic Range | Total (imipramine and desipramine): 150-300 ng/mL |
| Toxic Level | Greater than 500 ng/mL |
Interpretive Data
Toxic concentrations may cause anticholinergic effects, drowsiness and cardiac abnormalities.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
Report includes individual values for imipramine, desipramine, and total.
Hotline History
CPT Codes
80335 (Alt code: G0480)
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0090065 | Desipramine, SP | 3531-1 |
| 0090135 | Imipramine/Desipramine Total, SP | 9627-1 |
| 0090139 | Imipramine, SP | 3690-5 |
Aliases
- Antideprin
- Deprenyl
- Deprimin
- Deprinol
- Desipramine/Imipramine
- Eupramin
- Imipramil
- Imipramine and Metabolite
- Imipramine/Desipramine Fractionation
- Impril
- Irmin
- Janimine
- Melepramin
- Norpramin
- Novo-Parmine
- Presamine
- Surplix
- TCA
- Tofranil
- Tricyclic Antidepressants
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