Optimize drug therapy and monitor patient adherence.
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Mon, Wed, Fri
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.
Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2 EDTA).
Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).
After separation from cells: Ambient: 5 days; Refrigerated: 2 weeks; Frozen: 6 months
Effective February 19, 2013
|Therapeutic Range||Total (imipramine and desipramine): 150-300 ng/mL|
|Toxic Level||Greater than 500 ng/mL|
Toxic concentrations may cause anticholinergic effects, drowsiness and cardiac abnormalities.
Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
Report includes individual values for imipramine, desipramine, and total.
80335 (Alt code: G0480)
|Component Test Code*||Component Chart Name||LOINC|
|0090135||Imipramine/Desipramine Total, SP||9627-1|
- Imipramine and Metabolite
- Imipramine/Desipramine Fractionation
- Tricyclic Antidepressants