Ordering Recommendation

Optimize drug therapy and monitor patient adherence.


Quantitative Liquid Chromatography-Tandem Mass Spectrometry


Mon, Wed, Fri


1-5 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.


Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2 EDTA).

Specimen Preparation

Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature


Unacceptable Conditions

Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).


After separation from cells: Ambient: 5 days; Refrigerated: 2 weeks; Frozen: 6 months

Reference Interval

Effective February 19, 2013

Therapeutic Range Total (imipramine and desipramine): 150-300 ng/mL
Toxic Level Greater than 500 ng/mL

Interpretive Data

Toxic concentrations may cause anticholinergic effects, drowsiness and cardiac abnormalities.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.


Report includes individual values for imipramine, desipramine, and total.

Hotline History
CPT Codes

80335 (Alt code: G0480)

Component Test Code* Component Chart Name LOINC
0090065 Desipramine, SP 3531-1
0090135 Imipramine/Desipramine Total, SP 9627-1
0090139 Imipramine, SP 3690-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Antideprin
  • Deprenyl
  • Deprimin
  • Deprinol
  • Desipramine/Imipramine
  • Eupramin
  • Imipramil
  • Imipramine and Metabolite
  • Imipramine/Desipramine Fractionation
  • Impril
  • Irmin
  • Janimine
  • Melepramin
  • Norpramin
  • Novo-Parmine
  • Presamine
  • Surplix
  • TCA
  • Tofranil
  • Tricyclic Antidepressants
Imipramine and Desipramine, Serum or Plasma