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Antiviral Susceptibility, Herpes Simplex Virus, Acyclovir
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Ordering Recommendation
Use to determine in-vitro susceptibility of cultured herpes simplex virus (HSV) isolates to acyclovir. Testing requires HSV isolate not available from direct patient specimens. If direct patient specimen is sent for testing, add Herpes Simplex Virus Culture (0065005).
Mnemonic
Methodology
Cell Culture/Susceptibility Testing
Performed
Wed
Reported
14-21 days
New York DOH Approval Status
Specimen Required
Isolate from cell culture (3-4+ positivity).
Isolate from cell culture (3-4+ positivity). Place each specimen in an individually sealed bag.
Room temperature. Also acceptable: Refrigerated and frozen on dry ice.
Ambient: 48 hours; Refrigerated: 72 hours; Frozen at -70°C: 1 month
Reference Interval
Less than 2 µg/mL
Interpretive Data
A value of greater than or equal to 2 µg/mL suggests resistance.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
A processing fee will be billed for isolates that fail to grow to 3-4+ positivity as indicated in the specimen requirements.
For specimens other than isolates, herpes simplex virus (HSV) culture (test code 0065005) will be performed at ARUP. Additional charges apply.
Hotline History
CPT Codes
87252; 87253
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 2010868 | Acyclovir Interpretation | 73574-6 |
| 2010978 | Acyclovir IC50 Value | 9416-9 |
Aliases
- Acyclovir Resistance HSV
- Drug Resistance
- Herpes Simplex Types 1 and 2 virus Phenotyping
- Phenotyping for Acyclovir
- Zovirax Resistance
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