Ordering Recommendation

Use to determine in-vitro susceptibility of cultured herpes simplex virus (HSV) isolates to acyclovir. Testing requires HSV isolate not available from direct patient specimens. If direct patient specimen is sent for testing, add Herpes Simplex Virus Culture (0065005).


Cell Culture/Susceptibility Testing




14-21 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Isolate from cell culture (3-4+ positivity).

Specimen Preparation

Isolate from cell culture (3-4+ positivity). Place each specimen in an individually sealed bag.

Storage/Transport Temperature

Room temperature. Also acceptable: Refrigerated and frozen on dry ice.

Unacceptable Conditions

Ambient: 48 hours; Refrigerated: 72 hours; Frozen at -70°C: 1 month

Reference Interval

Less than 2 µg/mL

Interpretive Data

A value of greater than or equal to 2 µg/mL suggests resistance.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


A processing fee will be billed for isolates that fail to grow to 3-4+ positivity as indicated in the specimen requirements.
For specimens other than isolates, herpes simplex virus (HSV) culture (test code 0065005) will be performed at ARUP. Additional charges apply. 

Hotline History


CPT Codes

87252; 87253


Component Test Code* Component Chart Name LOINC
2010868 Acyclovir Interpretation 73574-6
2010978 Acyclovir IC50 Value 9416-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Acyclovir Resistance HSV
  • Drug Resistance
  • Herpes Simplex Types 1 and 2 virus Phenotyping
  • Phenotyping for Acyclovir
  • Zovirax Resistance
Antiviral Susceptibility, Herpes Simplex Virus, Acyclovir