Ordering Recommendation

Detect herpes simplex virus (HSV) resistance to acyclovir.

Mnemonic
HSVSUS ACV
Methodology

Cell Culture, Susceptibility

Performed

Wed

Reported

2-3 weeks

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Isolate from cell culture (3-4+ positivity).

Specimen Preparation

Isolate from cell culture (3-4+ positivity). Place each specimen in an individually sealed bag.

Storage/Transport Temperature

Room temperature. Also acceptable: Refrigerated and frozen on dry ice.

Unacceptable Conditions
Remarks
Stability

Ambient: 48 hours; Refrigerated: 72 hours; Frozen at -70°C: 1 month

Reference Interval

Less than 2 µg/mL

Interpretive Data

A value of greater than or equal to 2 µg/mL suggests resistance.

Compliance Category

Laboratory Developed Test (LDT)

Note

A processing fee will be billed for isolates that fail to grow to 3-4+ positivity as indicated in the specimen requirements. For specimens other than isolates (swabs) refer to Herpes Simplex Virus Culture (Test Number 0065005). 

Hotline History
N/A
CPT Codes

87252; 87253

Components
Component Test Code* Component Chart Name LOINC
2010868 Acyclovir Interpretation 73574-6
2010978 Acyclovir IC50 Value 9416-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Acyclovir Resistance HSV
  • Drug Resistance
  • Herpes Simplex Types 1 and 2 virus Phenotyping
  • Phenotyping for Acyclovir
  • Zovirax Resistance
Antiviral Susceptibility, Herpes Simplex Virus, Acyclovir