Ordering Recommendation

Preferred test to assess for hereditary form of cardiomyopathy or arrhythmia.

Mnemonic
CARDIACPAN
Methodology

Massively Parallel Sequencing

Performed

Varies

Reported

3-6 weeks

New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
Collect

Lavender (EDTA) or yellow (ACD Solution A or B).

Specimen Preparation

Transport 3 mL whole blood. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions
Remarks
Stability

Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable

Reference Interval

By report

Interpretive Data

Refer to report.

Compliance Category

Laboratory Developed Test (LDT)

Note

Genes Tested: ABCC9, ACTC1, ACTN2, ANK2, ANKRD1, BAG3**, CACNA1C, CACNB2, CASQ2, CAV3, CRYAB**, CSRP3, DES, DMD, DSC2, DSG2, DSP, DTNA, EMD**, EYA4, FHL1**, FKRP, FKTN, GAA, GATAD1**, GLA, GPD1L, JPH2, JUP, KCNE1, KCNE2, KCNE3, KCNH2, KCNJ2, KCNQ1, LAMA4, LAMP2, LDB3, LMNA, MYBPC3, MYH6, MYH7, MYL2, MYL3, MYLK2, MYOT, MYOZ2, MYPN, NEXN, PKP2, PLN, PRKAG2, RBM20, RYR2, SCN1B, SCN2B, SCN3B, SCN4B, SCN5A, SGCA, SGCB, SGCD, SGCG, SLC25A4, SNTA1, TAZ**, TCAP, TGFB3, TMEM43, TNNC1, TNNI3, TNNT2, TPM1, TRDN**, TRPM4, TTN*, TTR, VCL
 
* One or more exons are not covered by sequencing for the indicated gene; see Additional Technical Information.
** Deletion/duplication detection is not available for this gene.

Hotline History
N/A
CPT Codes

81413; 81414

Components
Component Test Code* Component Chart Name LOINC
2010184 Cardiomyopathy/Arrhythmia Panel Specimen 31208-2
2010187 Cardiomyopathy/Arrhythmia Panel Interp 41103-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Arrhythmogenic right ventricular cardiomyopathy (ARVC)
  • Arrhythmogenic right ventricular dysplasia (ARVD)
  • Brugada syndrome (BrS)
  • Catecholaminergic polymorphic ventricular tachycardia (CPVT)
  • Dilated cardiomyopathy (DCM)
  • Familial dilated cardiomyopathy (FDC)
  • Familial polymorphic cardiomyopathy (FPVT)
  • Hypertrophic cardiomyopathy (HCM)
  • Jervell and Lange-Nielsen syndrome
  • Left ventricular noncompaction (LVNC)
  • Long QT syndrome (LQTS)
  • Romano-Ward
  • Short QT syndrome (SQTS)
  • Uhl anomaly
Cardiomyopathy and Arrhythmia Panel, Sequencing and Deletion/Duplication