2010183
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Cardiomyopathy and Arrhythmia Panel, Sequencing and Deletion/Duplication

CARDIACPAN
Example Reports
Negative
Positive

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Informed Consent for Genetic Testing (Required for NY Patients)

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Cardiomyopathy/Arrhythmia Genetic Testing Patient History Form

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Additional Technical Information

Ordering Recommendation

Preferred test to assess for hereditary form of cardiomyopathy or arrhythmia.

New York DOH Approval Status

Testing is not New York state approved. Specimens from New York clients will be sent out to a New York state-approved laboratory.

Specimen Required

Patient Preparation
Collect

Lavender or pink (EDTA) or yellow (ACD solution A or B).
New York State Clients: Lavender (EDTA) or yellow (ACD solution A)

Specimen Preparation

Transport 3 mL whole blood. (Min: 3 mL)
New York State Clients: 5 mL (Min: 3 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Serum or plasma; grossly hemolyzed or frozen specimens; saliva, buccal brush, or swab; FFPE tissue.

Remarks
Stability

Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable
New York State Clients: Ambient: 48 hours; Refrigerated: 1 week; Frozen: Unacceptable

Methodology

Massively Parallel Sequencing

Performed

Varies

Reported

14-21 days

Reference Interval

Refer to report

Interpretive Data

Refer to report.

Compliance Category

Laboratory Developed Test (LDT)

Note

Genes Tested: ABCC9; ACTC1; ACTN2; AGL; ALMS1; ALPK3; BAG3; BRAF*; CACNA1C; CALM1*; CALM2; CALM3; CASQ2; CRYAB; CSRP3*; DES*; DMD; DOLK; DSC2; DSG2; DSP; EMD; FHL1*; FKTN*; FLNC*; GAA; GLA; HCN4; HRAS; JPH2; JUP; KCNE1; KCNE2; KCNH2*; KCNJ2; KCNQ1; KRAS; LAMP2; LDB3; LMNA; MAP2K1; MAP2K2*; MYBPC3; MYH6*; MYH7*; MYL2; MYL3; NEXN; NKX2-5; NRAS; PKP2*; PLN; PRDM16; PRKAG2*; PTPN11**; RAF1*; RBM20; RIT1*; RYR2; SCN5A; SOS1*; TAFAZZIN; TCAP; TECRL*; TMEM43; TNNC1; TNNI3; TNNI3K; TNNT2; TPM1*; TRDN*; TTN*; TTR; VCL

*One or more exons are not covered by sequencing and/or deletion/duplication analysis for the indicated gene; see Additional Technical Information.
**Deletion/duplication detection is not available for this gene.

When testing cord blood specimens, the presence of maternal cell contamination (MCC) is possible, which may impact result interpretation. If clinically warranted, testing for MCC is available, at a charge, through ARUP Laboratories.

Hotline History

N/A

CPT Codes

81403; 81404; 81405; 81406; 81407; 81408; 81479; 81414

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Components

Component Test Code* Component Chart Name LOINC
2010184 Cardiomyopathy/Arrhythmia Panel Specimen 31208-2
2010187 Cardiomyopathy/Arrhythmia Panel Interp 41103-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Arrhythmogenic right ventricular cardiomyopathy (ARVC)
  • arrhythmogenic right ventricular dysplasia (ARVD)
  • atrial septal defect with or without AV conduction defects
  • Brugada syndrome (BrS)
  • catecholaminergic polymorphic ventricular tachycardia (CPVT)
  • dilated cardiomyopathy (DCM)
  • familial dilated cardiomyopathy (FDC)
  • familial polymorphic cardiomyopathy (FPVT)
  • hypertrophic cardiomyopathy (HCM)
  • Jervell and Lange-Nielsen syndrome
  • left ventricular noncompaction (LVNC)
  • long QT syndrome (LQTS)
  • Noonan syndrome
  • Romano-Ward
  • short QT syndrome (SQTS)
  • sick sinus syndrome
  • Uhl anomaly
Cardiomyopathy and Arrhythmia Panel, Sequencing and Deletion/Duplication