Cardiomyopathy and Arrhythmia Panel, Sequencing and Deletion/Duplication

2010183
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Example Reports
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Patient History for Cardiomyopathy/Arrhythmia Genetic Testing

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Additional Technical Information

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Test not New York DOH approved at any laboratory. An approved NPL form must accompany specimen.
Ordering Recommendation

Preferred test to assess for hereditary form of cardiomyopathy or arrhythmia.

Mnemonic
CARDIACPAN
Methodology

Massively Parallel Sequencing

Performed

Varies

Reported

3-6 weeks

New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
Collect

Lavender (EDTA) or yellow (ACD Solution A or B).

Specimen Preparation

Transport 3 mL whole blood. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions
Remarks
Stability

Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable

Reference Interval

By report

Interpretive Data

Refer to report.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Counseling and informed consent are recommended for genetic testing. Consent forms are available online.

Compliance Category

Laboratory Developed Test (LDT)

Note

Genes Tested: ABCC9, ACTC1, ACTN2, ANK2, ANKRD1, BAG3**, CACNA1C, CACNB2, CASQ2, CAV3, CRYAB**, CSRP3, DES, DMD, DSC2, DSG2, DSP, DTNA, EMD**, EYA4, FHL1**, FKRP, FKTN, GAA, GATAD1**, GLA, GPD1L, JPH2, JUP, KCNE1, KCNE2, KCNE3, KCNH2, KCNJ2, KCNQ1, LAMA4, LAMP2, LDB3, LMNA, MYBPC3, MYH6, MYH7, MYL2, MYL3, MYLK2, MYOT, MYOZ2, MYPN, NEXN, PKP2, PLN, PRKAG2, RBM20, RYR2, SCN1B, SCN2B, SCN3B, SCN4B, SCN5A, SGCA, SGCB, SGCD, SGCG, SLC25A4, SNTA1, TAZ**, TCAP, TGFB3, TMEM43, TNNC1, TNNI3, TNNT2, TPM1, TRDN**, TRPM4, TTN*, TTR, VCL
 
* One or more exons are not covered by sequencing for the indicated gene; see Additional Technical Information.
** Deletion/duplication detection is not available for this gene.

Hotline History
N/A
CPT Codes

81413; 81414

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Components
Component Test Code* Component Chart Name LOINC
2010184 Cardiomyopathy/Arrhythmia Panel Specimen 31208-2
2010187 Cardiomyopathy/Arrhythmia Panel Interp 41103-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Arrhythmogenic right ventricular cardiomyopathy (ARVC)
  • Arrhythmogenic right ventricular dysplasia (ARVD)
  • Brugada syndrome (BrS)
  • Catecholaminergic polymorphic ventricular tachycardia (CPVT)
  • Dilated cardiomyopathy (DCM)
  • Familial dilated cardiomyopathy (FDC)
  • Familial polymorphic cardiomyopathy (FPVT)
  • Hypertrophic cardiomyopathy (HCM)
  • Jervell and Lange-Nielsen syndrome
  • Left ventricular noncompaction (LVNC)
  • Long QT syndrome (LQTS)
  • Romano-Ward
  • Short QT syndrome (SQTS)
  • Uhl anomaly
Cardiomyopathy and Arrhythmia Panel, Sequencing and Deletion/Duplication