Ordering Recommendation

Preferred test to follow-up presumptive results. For general screening, Buprenorphine, Urine Screen with Reflex to Quantitation (2012273) is preferred.

Mnemonic
BUPR UR
Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Performed

Sun-Sat

Reported

1-4 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Random urine.

Specimen Preparation

Transfer 2 mL urine with no additives or preservatives to an ARUP Standard Transport Tube. (Min: 1 mL)

Storage/Transport Temperature

Room temperature.

Unacceptable Conditions
Remarks
Stability

Ambient: 1 week; Refrigerated: 1 month; Frozen: 3 years (Avoid repeated freeze/thaw cycles)

Reference Interval

Effective August 17, 2015

Drugs Covered Cutoff Concentrations
Buprenorphine 2 ng/mL
Norbuprenorphine 2 ng/mL
Buprenorphine glucuronide 5 ng/mL
Norbuprenorphine glucuronide 5 ng/mL
Naloxone 100 ng/mL

Interpretive Data

Methodology: Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Positive cutoff:
Buprenorphine                       2 ng/mL
Norbuprenorphine                    2 ng/mL
Buprenorphine glucuronide           5 ng/mL
Norbuprenorphine glucuronide        5 ng/mL
Naloxone                             100 ng/mL


For medical purposes only; not valid for forensic use.

The presence of metabolite(s) without parent drug is common and may indicate use of parent drug during the prior week. Naloxone is included to detect the addition of a naloxone-containing drug directly into the urine.

The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, diluted/adulterated urine, or limitations of testing. The concentration value must be greater than or equal to the cutoff to be reported as positive. Interpretive questions should be directed to the laboratory.

Compliance Category

Laboratory Developed Test (LDT)

Note
Hotline History
N/A
CPT Codes

80348 (Alt code: G0480)

Components
Component Test Code* Component Chart Name LOINC
2002750 Norbuprenorphine, Urn, Quant 49753-7
2002752 Buprenorphine, Urn, Quant 3415-7
2005863 Naloxone, Urn, Quant 77207-9
2010093 Buprenorphine Gluc, Urn, Quant
2010094 Norbuprenorphine Gluc, Urn, Quant 49751-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Belbuca
  • Buprenex
  • Butrans
  • Medication Adherence
  • Narcan
  • Opioids use disorders
  • Pain Management
  • Probuphine
  • Sublocade
  • Suboxone
  • Subutex
  • Temgesic
  • Transtec
  • Vetergesic
  • Zubsolv
Buprenorphine and Metabolites, Urine, Quantitative