Encephalitis Panel with Reflex to Herpes Simplex Virus Types 1 and 2 Glycoprotein G-Specific Antibodies, IgG, CSF

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Test not New York DOH approved at any laboratory. An approved NPL form must accompany specimen.

Ordering Recommendation

Molecular testing is preferred for patients presenting with meningitis/encephalitis. Refer to Meningitis/Encephalitis Panel by PCR (2013305).

Mnemonic

ENCEPHCSF

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Chemiluminescent Immunoassay

Performed

Sun-Sat

Reported

4-6 days

New York DOH Approval Status

Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.

Specimen Required

Patient Preparation
Collect

CSF.

Specimen Preparation

Transfer 3 mL CSF to an ARUP Standard Transport Tube. (Min: 1.05 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Serum or plasma. Contaminated, heat-inactivated, or hemolyzed specimens.

Remarks
Stability

Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval

Test Number
 Components
 Reference Interval
  West Nile Virus Antibody IgG CSF 1.29 IV or less
  Measles, Rubeola, Antibody IgM CSF 0.79 AU or less
  West Nile Virus Antibody IgM CSF 0.89 IV or less
  HSV 1/2 Antibody Screen IgG, CSF 0.89 IV or less
  HSV 1 and/or 2 Antibodies IgM, CSF 0.89 IV or less
  Measles, Rubeola, Antibody IgG CSF 16.4 AU/mL or less
  Mumps Virus Antibody IgG CSF 10.9 AU/mL or less
  Mumps Virus Antibody IgM CSF 0.79 IV or less
  VZV Antibody IgM CSF 0.90 ISR or less

Interpretive Data

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.


Component Interpretation
Measles (Rubeola) Antibody, IgG, CSF 13.4 AU/mL or less  Negative - No significant level of IgG antibody to measles (rubeola) virus detected.
13.5-16.4 AU/mL  Equivocal - Repeat testing in 10-14 days may be helpful.
16.5 AU/mL or greater  Positive - IgG antibody to measles (rubeola) detected, which may indicate a current or past measles (rubeola) infection.
Measles (Rubeola) Antibody, IgM, CSF 0.79 AU or less  Negative - No significant level of IgM antibodies to measles (rubeola) virus detected.
0.80-1.20 AU  Equivocal - Repeat testing in 10-14 days may be helpful.
1.21 AU or greater  Positive - IgM antibodies to measles (rubeola) virus detected. Suggestive of current or recent infection or immunization.  However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection or immunization.
Mumps Virus Antibody IgG, CSF 8.9 AU/mL or less  Negative - No significant level of detectable IgG mumps virus antibody.
9.0-10.9 AU/mL  Equivocal - Repeat testing in 10-14 days may be helpful.
11.0 AU/mL or greater  Positive - IgG antibody to mumps virus detected, which may indicate a current or past mumps virus infection.
Mumps Virus Antibody IgM, CSF 0.79 IV or less  Negative - No significant level of detectable IgM antibody to Mumps virus.
0.80-1.20 IV  Equivocal - Borderline levels of IgM antibody to Mumps virus. Repeat testing in 10-14 days may be helpful.
1.21 IV or greater  Positive - Presence of IgM antibody to Mumps virus detected, which may indicate a current or recent infection. However, low levels of IgM antibody may occasionally persist for more than 12 months post-infection or immunization.
Varicella-Zoster Virus Antibody, IgG, CSF 134.9 IV or less  Negative - No significant level of IgG antibody to varicella-zoster virus detected.
135.0-164.9 IV  Equivocal - Repeat testing in 10-14 days may be helpful.
165.0 IV or greater  Positive - IgG antibody to varicella-zoster virus detected, which may indicate a current or past varicella-zoster infection.
Varicella-Zoster Virus Antibody, IgM by ELISA (CSF) 0.90 ISR or less  Negative - No significant level of IgM antibody to varicella-zoster virus detected.
0.91-1.09 ISR  Equivocal - Repeat testing in 10-14 days may be helpful.
1.10 ISR or greater  Positive - Significant level of IgM antibody to varicella-zoster virus detected, which may indicate current or recent infection.  However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection.
Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgM by ELISA, CSF 0.89 IV or less  Negative - No significant level of detectable HSV IgM antibody.
0.90-1.09 IV  Equivocal - Questionable presence of IgM antibodies.  Repeat testing in 10-14 days may be helpful.
1.10 IV or greater  Positive - IgM antibody to HSV detected, which may indicate a current or recent infection. However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection.
Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG, CSF 0.89 IV or less  Negative - No significant level of detectable HSV IgG antibody.
0.90-1.09 IV  Equivocal - Questionable presence of IgG antibodies. Repeat testing in 10-14 days may be helpful.
1.10 IV or greater  Positive - IgG antibody to HSV detected which may indicate a current or past HSV infection.
West Nile Virus Antibody, IgG by ELISA, CSF 1.29 IV or less  Negative - No significant level of West Nile virus IgG antibody detected.
1.30-1.49 IV   Equivocal - Questionable presence of West Nile virus IgG antibody detected.  Repeat testing in 10-14 days may be helpful.
1.50 IV or greater  Positive - Presence of IgG antibody to West Nile virus detected, suggestive of current or past infection.
West Nile Virus Antibody, IgM by ELISA, CSF 0.89 IV or less  Negative - No significant level of West Nile virus IgM antibody detected.
0.90-1.10 IV  Equivocal - Questionable presence of West Nile virus IgM antibody detected.  Repeat testing in 10-14 days may be helpful.
1.11 IV or greater  Positive - Presence of IgM antibody to West Nile virus detected, suggestive of current or recent infection.

Compliance Category

Laboratory Developed Test (LDT)

Note

If HSV 1 and/or 2 IgG, CSF is 1.10 IV or greater, then HSV 1 G-Specific IgG, CSF and HSV 2 G-Specific IgG, CSF will be added. Additional charges apply.

Hotline History

N/A

CPT Codes

86765 x2; 86735 x2; 86787 x2; 86789; 86788; 86694 x2; if reflexed, add 86695; 86696

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Components

Component Test Code* Component Chart Name LOINC
0050238 West Nile Virus Antibody IgG CSF 39572-3
0050239 West Nile Virus Antibody IgM CSF 39573-1
0050394 HSV 1/2 Antibody Screen IgG, CSF 13249-8
0050408 HSV 1 and/or 2 Antibodies IgM, CSF 63432-9
0054440 Measles, Rubeola, Antibody IgG CSF 9566-1
0054441 Measles, Rubeola, Antibody IgM CSF 13283-7
0054442 Mumps Virus Antibody IgG CSF 13266-2
0054443 Mumps Virus Antibody IgM CSF 13267-0
0054444 VZV Antibody IgG CSF 58755-0
0054445 VZV Antibody IgM CSF 31695-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

Encephalitis Panel with Reflex to Herpes Simplex Virus Types 1 and 2 Glycoprotein G-Specific Antibodies, IgG, CSF