Ordering Recommendation

Molecular testing is preferred for patients presenting with meningitis/encephalitis. Refer to Meningitis/Encephalitis Panel by PCR (2013305).

Mnemonic
ENCEPHCSF
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Chemiluminescent Immunoassay

Performed

Sun-Sat

Reported

4-6 days

New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
Collect

CSF.

Specimen Preparation

Transfer 3 mL CSF to an ARUP Standard Transport Tube. (Min: 1.05 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Serum or plasma. Contaminated, heat-inactivated, or hemolyzed specimens.

Remarks
Stability

Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval
Test Number
Components
Reference Interval
0054440 Measles (Rubeola) Antibody, IgG, CSF Effective September 3, 2019
13.4 AU/mL or less Negative - No significant level of IgG antibody to measles (rubeola) virus detected.
13.5-16.4 AU/mL Equivocal - Repeat testing in 10-14 days may be helpful.
16.5 AU/mL or greater Positive - IgG antibody to measles (rubeola) detected, which may indicate a current or past measles (rubeola) infection.

0054441 Measles (Rubeola) Antibody, IgM, CSF
0.79 AU or less Negative - No significant level of IgM antibodies to measles (rubeola) virus detected.
0.80-1.20 AU Equivocal - Repeat testing in 10-14 days may be helpful.
1.21 AU or greater Positive - IgM antibodies to measles (rubeola) virus detected. Suggestive of current or recent infection or immunization.  However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection or immunization.

0054442 Mumps Virus Antibody IgG, CSF Effective August 20, 2012
8.9 AU/mL or less Negative - No significant level of detectable IgG mumps virus antibody.
9.0-10.9 AU/mL Equivocal - Repeat testing in 10-14 days may be helpful.
11.0 AU/mL or greater Positive - IgG antibody to mumps virus detected, which may indicate a current or past mumps virus infection.

0054443 Mumps Virus Antibody IgM, CSF
0.79 IV or less Negative - No significant level of detectable IgM antibody to Mumps virus.
0.80-1.20 IV Equivocal - Borderline levels of IgM antibody to Mumps virus. Repeat testing in 10-14 days may be helpful.
1.21 IV or greater Positive - Presence of IgM antibody to Mumps virus detected, which may indicate a current or recent infection. However, low levels of IgM antibody may occasionally persist for more than 12 months post-infection or immunization.

0054444 Varicella-Zoster Virus Antibody, IgG, CSF Effective February 18, 2020
134.9 IV or less Negative - No significant level of IgG antibody to varicella-zoster virus detected.
135.0-164.9 IV Equivocal - Repeat testing in 10-14 days may be helpful.
165.0 IV or greater Positive - IgG antibody to varicella-zoster virus detected, which may indicate a current or past varicella-zoster infection.

0054445 Varicella-Zoster Virus Antibody, IgM by ELISA (CSF)
0.90 ISR or less Negative - No significant level of IgM antibody to varicella-zoster virus detected.
0.91-1.09 ISR Equivocal - Repeat testing in 10-14 days may be helpful.
1.10 ISR or greater Positive - Significant level of IgM antibody to varicella-zoster virus detected, which may indicate current or recent infection.  However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection.

0050408 Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgM by ELISA, CSF
0.89 IV or less Negative - No significant level of detectable HSV IgM antibody.
0.90-1.09 IV Equivocal - Questionable presence of IgM antibodies.  Repeat testing in 10-14 days may be helpful.
1.10 IV or greater Positive - IgM antibody to HSV detected, which may indicate a current or recent infection. However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection.

0050394 Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG, CSF
0.89 IV or less Negative - No significant level of detectable HSV IgG antibody.
0.90-1.09 IV Equivocal - Questionable presence of IgG antibodies. Repeat testing in 10-14 days may be helpful.
1.10 IV or greater Positive - IgG antibody to HSV detected which may indicate a current or past HSV infection.

0050379 Herpes Simplex Virus Type 1 Glycoprotein G-Specific Antibody, IgG by ELISA, CSF
0.89 IV or less Negative - No significant level of detectable IgG antibody to HSV type 1 glycoprotein G.
0.90-1.10 IV Equivocal - Questionable presence of IgG antibody to HSV type 1.  Repeat testing in 10-14 days may be helpful.
1.11 IV or greater Positive - IgG antibody to HSV type 1 glycoprotein G detected, which may indicate a current or past infection.

0050359 Herpes Simplex Virus Type 2 Glycoprotein G-Specific Antibody, IgG by ELISA, CSF
0.89 IV or less Negative - No significant level of detectable IgG antibody to HSV type 2 glycoprotein G.
0.90-1.10 IV Equivocal - Questionable presence of IgG antibody to HSV type 2.  Repeat testing in 10-14 days may be helpful.
1.11 IV or greater Positive - IgG antibody to HSV type 2 glycoprotein G detected, which may indicate a current or past HSV infection.

0050238 West Nile Virus Antibody, IgG by ELISA, CSF
1.29 IV or less Negative - No significant level of West Nile virus IgG antibody detected.
1.30-1.49 IV Equivocal - Questionable presence of West Nile virus IgG antibody detected.  Repeat testing in 10-14 days may be helpful.
1.50 IV or greater Positive - Presence of IgG antibody to West Nile virus detected, suggestive of current or past infection.

0050239 West Nile Virus Antibody, IgM by ELISA, CSF
0.89 IV or less Negative - No significant level of West Nile virus IgM antibody detected.
0.90-1.10 IV Equivocal - Questionable presence of West Nile virus IgM antibody detected.  Repeat testing in 10-14 days may be helpful.
1.11 IV or greater Positive - Presence of IgM antibody to West Nile virus detected, suggestive of current or recent infection.

Interpretive Data



Compliance Category

Laboratory Developed Test (LDT)

Note

If HSV 1 and/or 2 IgG, CSF is 1.10 IV or greater, then HSV 1 G-Specific IgG, CSF and HSV 2 G-Specific IgG, CSF will be added. Additional charges apply.

Hotline History
N/A
CPT Codes

86765 x2; 86735 x2; 86787 x2; 86789; 86788; 86694 x2; if reflexed, add 86695; 86696

Components
Component Test Code* Component Chart Name LOINC
0050238 West Nile Virus Antibody IgG CSF 39572-3
0050239 West Nile Virus Antibody IgM CSF 39573-1
0050394 HSV 1/2 Antibody Screen IgG, CSF 13249-8
0050408 HSV 1 and/or 2 Antibodies IgM, CSF 63432-9
0054440 Measles, Rubeola, Antibody IgG CSF 9566-1
0054441 Measles, Rubeola, Antibody IgM CSF 13283-7
0054442 Mumps Virus Antibody IgG CSF 13266-2
0054443 Mumps Virus Antibody IgM CSF 13267-0
0054444 VZV Antibody IgG CSF 58755-0
0054445 VZV Antibody IgM CSF 31695-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
Encephalitis Panel with Reflex to Herpes Simplex Virus Types 1 and 2 Glycoprotein G-Specific Antibodies, IgG, CSF