Ordering Recommendation

Screening panel detects EGFR mutations (pyrosequencing), ALK and ROS1 fusion proteins (IHC).

Mnemonic

LUNG PANEL

Methodology

Polymerase Chain Reaction/Pyrosequencing/Immunohistochemistry

Performed

Varies

Reported

7-14 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Tumor tissue.

Specimen Preparation

Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Protect from excessive heat. Transport tissue block or 13 unstained 5-micron slides (8 on positively charged slides AND 5 on uncharged slides). (Min: 9 slides: 5 positively charged AND 4 uncharged) Tissue block will be returned after testing. Transport block and/or slide(s) in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect or contact ARUP Client Services at (800) 522-2787.

Storage/Transport Temperature

Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.

Unacceptable Conditions

Less than 25 percent tumor. Specimens fixed/processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives. Decalcified specimens.

Remarks

Include surgical pathology report.
If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of the following: an order comment indicating that the ARUP pathologist should choose the specimen most appropriate for testing (e.g., "Choose best block"), or individual orders for each sample submitted. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added to orders that utilize the first option. If multiple specimens are sent to ARUP without a request for pathologist block/slide selection or individual orders, they will be held until clarification is provided.

Stability

Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable

Reference Interval

Interpretive Data

Refer to report.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Panel consists of EGFR Mutation Detection by Pyrosequencing, ALK (D5F3) with Interpretation by Immunohistochemistry, and ROS1 with Interpretation by Immunohistochemistry with Reflex to FISH if Equivocal. If reflexed, additional charges apply.

Hotline History

N/A

CPT Codes

88381; 81235; 88342; 88341; if reflexed, add 88366

Components

Component Test Code* Component Chart Name LOINC
2002148 Block ID 57723-9
2002442 EGFR by Pyrosequencing 21665-5
2007325 ALK(D5F3) by IHC Reference Number 57723-9
2007327 ALK(D5F3) by IHC Result 35474-6
2008415 ROS1 by IHC Result
2008417 ROS1 Client Block ID
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

Lung Cancer Panel (INACTIVE as of 11/15/21: Refer to 2002440, 2007324, 2008414)