Use to assess for targeted variants that are useful for prognosis and/or treatment of individuals with solid tumor cancers, including melanoma, gastrointestinal stromal tumor (GIST), colorectal, bladder, and hepatocellular carcinomas, at initial diagnosis or in the presence of refractory disease. If the clinical indication is lung cancer, additional molecular genetic testing may be considered for detection of gene rearrangements and/or c-MET exon 14-skipping alterations. For evaluation of microsatellite instability, additional molecular testing should be considered.
Massively Parallel Sequencing
Varies
12-14 days
Tumor tissue.
Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Diff-Quik and Papanicolaou stained cytology smears are also acceptable. Number of slides needed is dependent on the tumor cellularity of the smear. Slide(s) will be destroyed during testing process and will not be returned to client. Protect from excessive heat. Transport block and/or slides in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787.
Resections: Transport 8 unstained 5-micron slides. (Min: 5 slides)
Small Biopsies: Transport 15 unstained 5-micron slides. (Min: 10 slides)
Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.
Less than 10 percent tumor. Specimens fixed/processed in heavy metal fixatives. Decalcified specimens. FNA smears with less than 50 tumor cells.
Include surgical pathology report.
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
Refer to report.
Laboratory Developed Test (LDT)
A full list of the targeted genes and regions is listed in the Additional Technical Information.
Hotline History
81445; 88381
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
2007992 | Solid Tumor Panel by NGS Block ID | |
2007993 | Solid Tumor Panel By NGS Interpretation | |
2008147 | EER Solid Tumor Panel by NGS |
- Solid Tumor Next Gen sequencing