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Solid Tumor Mutation Panel, Sequencing
Ordering Recommendation
Use to assess for targeted variants that are useful for prognosis and/or treatment of individuals with solid tumor cancers, including melanoma, gastrointestinal stromal tumor (GIST), colorectal, bladder, and hepatocellular carcinomas, at initial diagnosis or in the presence of refractory disease. If the clinical indication is lung cancer, additional molecular genetic testing may be considered for detection of gene rearrangements and/or c-MET exon 14-skipping alterations. For evaluation of microsatellite instability, additional molecular testing should be considered.
New York DOH Approval Status
Specimen Required
Tumor tissue.
Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue.
Diff-Quik- and Papanicolaou-stained cytology smears are also acceptable. Number of slides needed is dependent on the tumor cellularity of the smear. Slide(s) will be destroyed during testing process and will not be returned to client. Protect from excessive heat. Transport block and/or slides in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at 800-522-2787.
Resections: Transport 8 unstained 5-micron slides. (Min: 5 slides)
Small Biopsies: Transport 15 unstained 5-micron slides. (Min: 10 slides)
Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.
Less than 10 percent tumor. Specimens fixed in any fixative other than 10 percent neutral buffered formalin. Decalcified specimens. FNA smears with less than 50 tumor cells.
Include surgical pathology report.
If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of the following: an order comment indicating that the ARUP pathologist should choose the specimen most appropriate for testing (e.g., "Choose best block"), or individual orders for each sample submitted. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added to orders that utilize the first option. If multiple specimens are sent to ARUP without a request for pathologist block/slide selection or individual orders, they will be held until clarification is provided.
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
Methodology
Massively Parallel Sequencing
Performed
Varies
Reported
12-14 days
Reference Interval
Interpretive Data
Refer to report.
Laboratory Developed Test (LDT)
Note
A full list of the targeted genes and regions is listed in the Additional Technical Information.
Hotline History
CPT Codes
81445
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 2007992 | Solid Tumor Panel by NGS Block ID | 94736-6 |
| 2007993 | Solid Tumor Panel By NGS Interpretation | |
| 3003988 | EER Solid Tumor Panel NGS | 11502-2 |
Aliases
- Solid Tumor Next Gen sequencing
