Optimize drug therapy and monitor patient adherence. This test detects risperidone (parent) AND paliperidone (9-hydroxyrisperidone, metabolite). For paliperidone (9-hydroxyrisperidone) only, order Paliperidone, Serum or Plasma (2007949).
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Mon, Wed, Sat
New York DOH Approval Status
Pre-dose (trough) draw - At steady state concentration.
Plain Red. Also acceptable: Lavender (EDTA) or Pink (K2EDTA).
Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).
Ambient: 2 weeks; Refrigerated: 2 weeks; Frozen: 2 months
Effective June 7, 2021
|Therapeutic range (Risperidone)||20-60 ng/mL|
|Therapeutic range (9-hydroxyrisperidone (Paliperidone))||20-60 ng/mL|
|Toxic range (Risperidone and Metabolite)||Greater than 120 ng/mL|
The therapeutic range is based on serum pre-dose (trough) draw at steady-state concentration. Adverse effects to risperidone therapy may include headache, nausea, dizziness, tachycardia, orthostatic hypotension and dyskinesia.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
80342 (Alt code: G0480)
|Component Test Code*||Component Chart Name||LOINC|
|2007953||9 OH Risperidone Serum/Plasma||9383-1|
|2007954||Total Risper/9 OH Risper||9394-8|
- risperdal blood level
- risperidone blood level