Ordering Recommendation

Optimize drug therapy and monitor patient adherence. This test detects risperidone (parent) AND paliperidone (9-hydroxyrisperidone, metabolite). For paliperidone (9-hydroxyrisperidone) only, order Paliperidone, Serum or Plasma (2007949).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Pre-dose (trough) draw - At steady state concentration.

Collect

Plain Red. Also acceptable: Lavender (EDTA) or Pink (K2EDTA).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).

Remarks

N/A

Stability

Ambient: 2 weeks; Refrigerated: 2 weeks; Frozen: 2 months

Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Performed

Mon, Wed, Sat

Reported

1-7 days

Reference Interval

Therapeutic range (Risperidone) 20-60 ng/mL
Therapeutic range (9-hydroxyrisperidone (Paliperidone)) 20-60 ng/mL
Toxic range (Risperidone and Metabolite) Greater than 120 ng/mL

Interpretive Data

The therapeutic range is based on serum pre-dose (trough) draw at steady-state concentration. Adverse effects to risperidone therapy may include headache, nausea, dizziness, tachycardia, orthostatic hypotension and dyskinesia.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

N/A

CPT Codes

80342 (Alt code: G0480)

Components

Component Test Code* Component Chart Name LOINC
2007952 Risperidone Serum/Plasma 9393-0
2007953 9 OH Risperidone Serum/Plasma 9383-1
2007954 Total Risper/9 OH Risper 9394-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • 9-Hydroxyrisperidone
  • risperdal blood level
  • Risperdal{R}
  • risperidone blood level
Risperidone and Metabolite, Serum or Plasma