Ordering Recommendation

Optimize drug therapy and monitor patient adherence. This test detects risperidone (parent) AND paliperidone (9-hydroxyrisperidone, metabolite). For paliperidone (9-hydroxyrisperidone) only, order Paliperidone, Serum or Plasma (2007949).




Quantitative Liquid Chromatography-Tandem Mass Spectrometry


Mon, Wed, Sat


1-5 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Pre-dose (trough) draw - At steady state concentration.


Lavender (EDTA), pink (K2EDTA) or plain red.

Specimen Preparation

Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature


Unacceptable Conditions

Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).




Ambient: 2 weeks; Refrigerated: 2 weeks; Frozen: 2 months

Reference Interval

Therapeutic range Not well established
Total (Risperidone and Metabolite) 20-60 ng/mL
Toxic range Not well established

Interpretive Data

Adverse effects to risperidone therapy may include headache, nausea, dizziness, tachycardia, orthostatic hypotension and dyskinesia.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


Hotline History


CPT Codes

80342 (Alt code: G0480)


Component Test Code* Component Chart Name LOINC
2007952 Risperidone Serum/Plasma 9393-0
2007953 9 OH Risperidone Serum/Plasma 9383-1
2007954 Total Risper/9 OH Risper 9394-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • 9-Hydroxyrisperidone
  • risperdal blood level
  • Risperdal{R}
  • risperidone blood level
Risperidone and Metabolite, Serum or Plasma