Ordering Recommendation

Optimize drug therapy and monitor patient adherence. This test detects paliperidone (9-hydroxyrisperidone) only. For risperidone (parent) AND paliperidone (9-hydroxyrisperidone, metabolite), order Risperidone and Metabolite, Serum or Plasma (2007951).

Mnemonic
PALIPERID
Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Performed

Wed, Sat

Reported

1-5 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Pre-dose (trough) draw - At steady state concentration.

Collect

Lavender (EDTA), Pink (K2EDTA), or Plain Red.

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).

Remarks
Stability

Ambient: 2 weeks; Refrigerated: 2 weeks; Frozen: 2 months

Reference Interval
Therapeutic range: Not well established
Proposed Dose-Related Range: Paliperidone (9-hydroxyrisperidone): 20 - 60 ng/mL
Toxic range: Not well established

Interpretive Data

The therapeutic range is based on serum pre-dose (trough) draw at steady-state concentration. Adverse effects to paliperidone therapy may include headache, nausea, dizziness, tachycardia, orthostatic hypotension and dyskinesia.

Compliance Category

Laboratory Developed Test (LDT)

Note
Hotline History
N/A
CPT Codes

80342 (Alt code: G0480)

Components
Component Test Code* Component Chart Name LOINC
2007950 Paliperidone, Serum/Plasma 9383-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • 9-hydroxyrisperidone
  • Invega
  • invega blood level
Paliperidone, Serum or Plasma