Ordering Recommendation

Optimize drug therapy and monitor patient adherence. This test detects paliperidone (9-hydroxyrisperidone) only. For risperidone (parent) AND paliperidone (9-hydroxyrisperidone, metabolite), order Risperidone and Metabolite, Serum or Plasma (2007951).

Mnemonic

PALIPERID

Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Performed

Wed, Sat

Reported

1-5 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Pre-dose (trough) draw - At steady state concentration.

Collect

Lavender (EDTA), Pink (K2EDTA), or Plain Red.

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).

Remarks
Stability

Ambient: 2 weeks; Refrigerated: 2 weeks; Frozen: 2 months

Reference Interval

Therapeutic range: Not well established
Proposed Dose-Related Range: Paliperidone (9-hydroxyrisperidone): 20 - 60 ng/mL
Toxic range: Not well established

Interpretive Data

The therapeutic range is based on serum pre-dose (trough) draw at steady-state concentration. Adverse effects to paliperidone therapy may include headache, nausea, dizziness, tachycardia, orthostatic hypotension and dyskinesia.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

N/A

CPT Codes

80342 (Alt code: G0480)

Components

Component Test Code* Component Chart Name LOINC
2007950 Paliperidone, Serum/Plasma 9383-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • 9-hydroxyrisperidone
  • Invega
  • invega blood level
Paliperidone, Serum or Plasma