Ordering Recommendation

Recommended for determination of iodine excess and monitoring iodine overload in patients administered iodine-containing medications. This test reports total iodine from all iodine-containing species present in the specimen but does not determine the chemical form (species) of the iodine present. For the assessment of nutritional status, Iodine, Urine (2007465) is preferred.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, nonessential over-the-counter medications for 48 hours (upon the advice of their physician). In addition, the administration of iodine-based contrast media and drugs containing iodine may yield elevated results. During venipuncture, do not use disinfectants (such as Betadine) that contain iodine.


Royal blue (no additive).

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transport 2 mL serum in an ARUP Trace Element-Free Transport Tube (ARUP supply #43116) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 0.5 mL)

Storage/Transport Temperature


Unacceptable Conditions

Specimens not received in Trace Element Free transport tubes. Separator tubes and specimens that are not separated from the clot within 2 hours. Serum collected within 48 hours after administration of a gadolinium (Gd) or iodine (I) containing contrast media (may occur with MRI studies). Plasma.


Ambient: 30 days; Refrigerated: 30 days; Frozen: 30 days


Quantitative Inductively Coupled Plasma-Mass Spectrometry


Tue, Thu, Sat


1-5 days

Reference Interval

40-92 µg/L

Interpretive Data

Values greater than 250 µg/L may indicate iodine overload.

Elevated results may be due to skin or collection-related contamination, including the use of a noncertified metal-free collection/transport tube. If contamination concerns exist due to elevated levels of serum iodine, confirmation with a second specimen collected in a certified metal-free tube is recommended.

Compliance Category

Laboratory Developed Test (LDT)


Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
2007464 Iodine, Serum 2494-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • I serum
  • Iodide
  • serum iodine
  • serum iodine concentration
Iodine, Serum