Ordering Recommendation

Urine screening test for determining active exposure to nicotine and compliance with smoking-cessation programs. For determination of active or passive nicotine use, or for differentiation between nicotine replacement and tobacco use, Nicotine and Metabolites, Urine, Quantitative (0092356) is preferred.

Mnemonic

COTININE

Methodology

Enzyme Multiplied Immunoassay Technique

Performed

Sun-Sat

Reported

1-5 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Random urine

Specimen Preparation

Transfer 4 mL urine with no additives to an ARUP Standard Transport Tube. (Min: 2 mL)

Storage/Transport Temperature

Refrigerated

Unacceptable Conditions

Specimens exposed to repeated freeze/thaw cycles

Remarks
Stability

Ambient: 1 week; Refrigerated: 1 week; Frozen: 3 months

Reference Interval

Negative

Interpretive Data

Cotinine is a metabolite of nicotine and may be detected up to seven days after nicotine exposure. The cutoff is set at 100 ng/mL to detect active exposure (smoking).  This test will not distinguish between tobacco use and nicotine replacement therapy.

Compliance Category

FDA

Note

Hotline History

N/A

CPT Codes

80307

Components

Component Test Code* Component Chart Name LOINC
2007082 Cotinine, Urn, Screen 12293-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Nicotine & Metabolites urine
  • Nicotine Metabolite
Cotinine Screen, Urine