Ordering Recommendation
Use in cases of Philadelphia chromosome positive (Ph+) lymphoblastic leukemia to quantify the BCR-ABL1 p190 fusion form. For CML, use Quantitative Detection of BCR-ABL1, Major Form (p210) (3005840).
Mnemonic
Methodology
Quantitative Reverse Transcription Polymerase Chain Reaction
Performed
Sun, Tue, Thu
Reported
5-9 days
New York DOH Approval Status
Specimen Required
Lavender (EDTA) or bone marrow (EDTA). Also acceptable: RNA extracted by CLIA-certified lab.
Whole Blood: Transport 5 mL whole blood. (Min: 1 mL)
Bone Marrow: Transport 3 mL bone marrow. (Min: 1 mL)
Specimens must be received within 48 hours of collection due to lability of RNA.
Extracted RNA: Transport 40 uL RNA with at least 40 ng/uL concentration. (Min: 40 uL) Transport RNA in a tissue transport kit (ARUP Supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at 800-522-2787.
Whole Blood or Bone Marrow: CRITICAL REFRIGERATED. Separate specimens must be submitted when multiple tests are ordered.
Extracted RNA: CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Serum, plasma, CSF, extracted DNA, RNA extracted by a non-CLIA lab, bone core, or FFPE tissue. Specimens collected in anticoagulants other than EDTA. Severely hemolyzed or clotted specimens.
Ambient: 1 hour; Refrigerated: 48 hours; Frozen: Unacceptable
Extracted RNA: Ambient: Unacceptable; Refrigerate: Unacceptable; Frozen: Indefinitely
Reference Interval
Interpretive Data
Refer to report.
Laboratory Developed Test (LDT)
Note
For p210 fusion form (major breakpoint), order BCR-ABL1, Major (p210), Quantitative (ARUP test code 3005840).
Hotline History
Hotline History
CPT Codes
81207
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0051095 | BCR-ABL1, t(9;22) Source | 31208-2 |
2005007 | BCR-ABL1, Minor (p190) Result | 21823-0 |
2005008 | BCR-ABL1/ABL1, Minor (p190) Quant Ratio | 52132-8 |
2005009 | EER BCR-ABL1, Minor (p190) | 11526-1 |
Aliases
- p190
- PH1
- philadelphia chromosome
- Philadelphia MS
- t(9;22)