Ordering Recommendation

Use in cases of Philadelphia chromosome positive (Ph+) lymphoblastic leukemia to quantify the BCR-ABL1 p190 fusion form. For CML, use Quantitative Detection of BCR-ABL1, Major Form (p210) (3005840).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Whole blood or bone marrow in lavender (EDTA).

Specimen Preparation

Whole Blood: Transport 5 mL whole blood. (Min: 3 mL)
Bone Marrow: Transport 3 mL bone marrow. (Min: 1 mL)
Refrigerate Immediately. Specimens must be received within 48 hours of collection due to lability of RNA.

Storage/Transport Temperature

Whole Blood or Bone Marrow: CRITICAL REFRIGERATED. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Serum, plasma, extracted DNA, CSF, FFPE tissue, ambient whole blood, or frozen whole blood or bone marrow.
Specimens collected in anticoagulants other than EDTA. Severely hemolyzed or clotted specimens.
Ambient bone marrow specimens past 7 days will be canceled.
Refrigerated whole blood or bone marrow specimens past 7 days will be canceled.

Remarks
Stability

Ambient: Unacceptable; Refrigerated: 48 hours; Frozen: Unacceptable

Methodology

Quantitative Reverse Transcription Polymerase Chain Reaction

Performed

Varies

Reported

5-9 days

Reference Interval

Interpretive Data

Refer to report.

Compliance Category

Laboratory Developed Test (LDT)

Note

For p210 fusion form (major breakpoint), order BCR-ABL1, Major (p210), Quantitative (ARUP test code 3005840).

Hotline History

N/A

CPT Codes

81207

Components

Component Test Code* Component Chart Name LOINC
0051095 BCR-ABL1, t(9;22) Source 31208-2
2005007 BCR-ABL1, Minor (p190) Result 21823-0
2005008 BCR-ABL1/ABL1, Minor (p190) Quant Ratio 52132-8
2005009 EER BCR-ABL1, Minor (p190) 11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • p190
  • PH1
  • philadelphia chromosome
  • Philadelphia MS
  • t(9;22)
BCR-ABL1, Minor (p190), Quantitative