Ordering Recommendation

May have diagnostic relevance in multifocal motor neuropathy (MMN), Guillain-Barré syndrome (GBS), and Miller Fisher syndrome (MFS). For a more comprehensive ganglioside antibody panel when evaluating patients with autoimmune neuropathies, refer to Ganglioside (Asialo-GM1, GM1, GM2, GD1a, GD1b, and GQ1b) Antibodies (0051033). Test by itself is not diagnostic and should be used in conjunction with other clinical parameters to confirm disease.

Mnemonic
GM1 LIGHT
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Thu

Reported

1-8 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Transfer 0.3 mL serum to an ARUP Standard Transport Tube. (Min: 0.1 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

CSF, plasma, or other body fluids. Room temperature specimens. Contaminated, heat-inactivated, hemolyzed, severely icteric, or lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: Unacceptable; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval
Test Number
Components
Reference Interval
0050591 Ganglioside (GM1) Antibodies, IgG and IgM
Test Number
Components
Reference Interval
GM1 Antibody IgG 29 IV or less: Negative
30-50 IV: Equivocal
51-100 IV: Positive
101 IV or greater: Strong Positive
GM1 Antibody, IgM 29 IV or less: Negative
30-50 IV: Equivocal
51-100 IV: Positive
101 IV or greater: Strong Positive

  GD1b Antibody, IgM
29 IV or less Negative
30-50 IV Equivocal
51-100 IV Positive
101 IV or greater Strong positive

  GD1b Antibody, IgG
29 IV or less Negative
30-50 IV Equivocal
51-100 IV Positive
101 IV or greater Strong positive

  GQ1b Antibody, IgG
29 IV or less Negative
30-50 IV Equivocal
51-100 IV Positive
101 IV or greater Strong positive

  GQ1b Antibody, IgM
29 IV or less Negative
30-50 IV Equivocal
51-100 IV Positive
101 IV or greater Strong positive

Interpretive Data

Refer to report.

Compliance Statement D: For laboratory tests using a manufactured RUO kit. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
Hotline History
N/A
CPT Codes

83516 x6

Components
Component Test Code* Component Chart Name LOINC
0050582 GM1 Antibody, IgG 51729-2
0050584 GM1 Antibody, IgM 51703-7
2004999 GD1b Antibody, IgG 56541-6
2005000 GD1b Antibody, IgM 58977-0
2005001 GQ1b Antibody, IgG 57660-3
2005002 GQ1b Antibody, IgM 56545-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Anti-GM Antibodies
  • Ganglioside Antibodies
  • Ganglioside (GM1) Antibodies, IgG and IgM
  • Ganglioside Abs IgG and IgM
  • GD1b IgG IgM
  • GM1, GD1b, GQ1b IgG and IgM
  • GQ1b IgG IgM
Ganglioside (GM1, GD1b, and GQ1b) Antibodies, IgG and IgM